Académicos(as)
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Dr. Joel Alderete
Perfil
Nuestras líneas de investigación están asociadas al empleo de biomateriales para aplicaciones en nanomedicina. Actualmente estamos enfocados en el desarrollo de cuatro temas específicos:
- Diseño y síntesis de nanotransportadores de fármacos con potencial para atravesar la barrera hemato-encefálica, y su uso en enfermedades del sistema nervioso central.
- Diseño y síntesis de nanotransportadores híbridos basados en nanotubos de óxidos metálicos.
- Síntesis de biomateriales híbridos y su utilización en fototerapia antimicrobiana.
- Diseño de conjugados dendrímero-fotosensibilizador para su utilización en terapia fotodinámica.
Formación Profesional
- Licenciado en Química, Universidad de Concepción (1990)
- Doctor en Ciencias con mención en Química, Universidad de Concepción (1995)
- Posición posdoctoral, Biological Chemistry Laboratory
Líneas de Investigación
Proyectos Vigentes
Proyecto: FONDECYT Regular 1170426
Título: Novel PAMAM-Based Drug Nanocarriers with Potential Applications in Central Nervous System Diseases.
Rol: Investigador Responsable
Periodo: 2017-2020
Proyecto: FONDECYT Regular 1160060
Título: Structure-based drug design of new tubulin binding agents with potential anticancer properties.
Rol: Co-Investigador
Periodo: 2016-2019
Proyecto: Fondo institucional de fomento regional para el desarrollo científico, tecnológico y de innovación CONACYT-MEXICO.
Título: Impulso a la capacitación especializada, al desarrollo e innovación tecnológica en el área de fabricación de micro- y nano-dispositivos.
Rol: Colaborador extranjero (Chile)
Periodo: 2016-2019
Publicaciones
• Cytotoxicity and in vivo plasma kinetic behavior of surface-functionalized PAMAM dendrimers. Carola Diaz ; Carolina Benitez; Felipe Vidal; Luis F. Barraza; Veronica A. Jimenez; Leonardo Guzman; Jorge Fuentealba ; Gonzalo E. Yevenes; Joel B. Alderete, NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE 14, 2227-2234 (2018).
• Partially PEGylated PAMAM dendrimers as solubility enhancers of Silybin. Carola Diaz, C ; Jose Guzman; Veronica A. Jimenez ; Joel B. Alderete, PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY 23, 689-696 (2018).
• Polyamido amine (PAMAM)-grafted magnetic nanotubes as emerging platforms for the delivery and sustained release of silibinin. Chavez, Gloria; Campos, Cristian H; Jimenez, Veronica A; Torres, Cecilia C ; Diaz, Carola; Salas, Gorka; Guzman, Leonardo; Alderete, Joel B. JOURNAL OF MATERIALS SCIENCE 52, 9269-9281 (2017).
• Association of Methotrexate with Native and PEGylated PAMAM-G4 Dendrimers: Effect of the PEGylation Degree on the Drug-Loading Capacity and Preferential Binding Sites. Luis F. Barraza ; Veronica A. Jimenez; Joel B. Alderete, JOURNAL OF PHYSICAL CHEMISTRY B 121, 4-12 (2017).
• PAMAM-Conjugated Alumina Nanotubes as Novel Noncytotoxic Nanocarriers with Enhanced Drug Loading and Releasing Performances. Cristian H. Campos; Carola F. Díaz; José L. Guzmán; Joel B. Alderete; Cecilia C. Torres; Verónica A. Jiménez, MACROMOLECULAR CHEMISTRY AND PHYSICS 217, 1712-1722 (2016).
• Partially PEGylated PAMAM dendrimers as solubility enhancers of Silybin. Carola Diaz, C ; Jose Guzman; Veronica A. Jimenez ; Joel B. Alderete, PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY 23, 689-696 (2018).
• Polyamido amine (PAMAM)-grafted magnetic nanotubes as emerging platforms for the delivery and sustained release of silibinin. Chavez, Gloria; Campos, Cristian H; Jimenez, Veronica A; Torres, Cecilia C ; Diaz, Carola; Salas, Gorka; Guzman, Leonardo; Alderete, Joel B. JOURNAL OF MATERIALS SCIENCE 52, 9269-9281 (2017).
• Association of Methotrexate with Native and PEGylated PAMAM-G4 Dendrimers: Effect of the PEGylation Degree on the Drug-Loading Capacity and Preferential Binding Sites. Luis F. Barraza ; Veronica A. Jimenez; Joel B. Alderete, JOURNAL OF PHYSICAL CHEMISTRY B 121, 4-12 (2017).
• PAMAM-Conjugated Alumina Nanotubes as Novel Noncytotoxic Nanocarriers with Enhanced Drug Loading and Releasing Performances. Cristian H. Campos; Carola F. Díaz; José L. Guzmán; Joel B. Alderete; Cecilia C. Torres; Verónica A. Jiménez, MACROMOLECULAR CHEMISTRY AND PHYSICS 217, 1712-1722 (2016).
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Dr. John Amalraj
Perfil
Nuestras líneas de investigación están asociadas al empleo de polímeros, nanocompositoes, hidrogeles y carbón nanotubos para aplicaciones en sensores, energía y biomédica. Actualmente estamos enfocados en las siguientes áreas:
- Síntesis y caracterización de nuevos polímeros funcionalizados para ser utilizados como catalizadores, sensores de moléculas de interés, capacitores y acumuladores de energía, interferencia electromagnética, etc.
- Diseño y caracterización de nuevos materiales inteligentes usando los biopolímeros como base, para ser empleados en aplicaciones biomédicas, ambiental y la electrónica.
- Análisis de compuestos orgánicos por método electroquímico.
Formación Profesional
- Bachiller en química Madurai Kamaraj Universisty, India. (1996-1999)
- Máster en Química Madurai Kamaraj Universisty, India. (1999-2001)
- Doctorado en Química Indian Institute of Chemical Technology (IICT), India (2003-2009)
- Postdoctorado Inha University, Corea del sur (2009-2011)
- Postdoctorado Fundación Fraunhofer Chile Research, Chile (2011-2015)
Líneas de Investigación
Proyectos Vigentes
Fondecyt Regular
- Synthesis of amidoxime functionalized biopolymers as a capping agent for the preparation of metal oxide nanoparticles and the development of smart metal oxide nanocomposite hydrogels for wound healing application (#1230561) (2023-2027) (Investigador Principal)
- Metal-Free Catalysis for the Asymmetric Synthesis of Bioactive Compounds, Co-investigator (#1220618) (2022-2026) (Co-Investigador)
- Synthesis of amidoxime functionalized biopolymers as a capping agent for the preparation of metal oxide nanoparticles and the development of smart metal oxide nanocomposite hydrogels for wound healing application (#1230561) (2023-2027) (Investigador Principal)
- Metal-Free Catalysis for the Asymmetric Synthesis of Bioactive Compounds, Co-investigator (#1220618) (2022-2026) (Co-Investigador)
- Synthesis and Characterization of Silica-Polyamidoamine (SiO2-PAMAM) Hybrid Material: A Novel Chiral Stationary Phase for HPLC. (#11130087) 2013-2016. (Investigador Principal)
- Síntesis de nanotubos de carbón decorados con nanopartículas de óxidos bimetálicos aplicados a la producción electrolítica de hidrógeno acoplada a electro-valorización de biomasa (#3220040, 2022-2025)
- Ultrasound-assisted extraction of flavonoids from tea and grape using co-immobilized enzymes in ionic liquid media (#3190136, 2019-2022)
- Bimetallic Oxide/Selenide-Functionalized Graphene Oxide-Chitosan Nanocomposite Hydrogels for the Electrochemical Detection of Neurotransmitters. (#3180312, 2018-2021)
- Development of homogeneous-sized biopolymer-metal nanocomposite hydrogels from chitosan and hydroxypropyl methylcellulose: prototype for antimicrobial applications (#3170272, 2017-2020)
- Development of a solar photoelectrochemical device for simultaneous generation of electric power and valuable molecules from glucose REDES 190062 (2019-2021) (Co-Investigador)
- Síntesis y funcionalización de carbón activado a partir de biomasa para la detección de disruptores endocrinos por método electroquímica (2023-2024) (Investigador Principal)
Publicaciones
- 1. Maomao Xie, Meng Gao, Yang Yun, Martin Malmsten, Vincent M. Rotello, Radek Zboril, Omid Akhavan, Aliaksandr Kraskouski, John Amalraj, Xiaoming Cai, Jianmei Lu, Huizhen Zheng, and Ruibin Li Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles Angew. Chem. Int. Ed. 2023, e202217345 (1 of 25) https://doi.org/10.1002/anie.202217345
- 2. Samira Hozhabr Araghi, Amalraj John*, Motahare Sadeghi Googheri, Radha D. Pyarasani, Mohammad Sadegh Sadeghi Googheri. An in-silico study to gain a comprehensive understanding of the effects of glucosylation on quercetin properties, Computational and Theoretical Chemistry, 1220, 2023, 113981, https://doi.org/10.1016/j.comptc.2022.113981
- 3. Romina Murga, Camila Rodriguez, John Amalraj, Dennis Vega, Leopoldo Gutierrez, Lina Uribe. Study of polystyrene nanoparticles as collectors in the recovery process of copper by flotation., Polymers 2022, 14, 5259. https://doi.org/10.3390/polym14235259
- 4. John Amalraj, Claudia E Vergara, Matías Monroy-Cárdenas, Ramiro Araya-Maturana, Maximiliano Martínez-Cifuentes Study of the Electrochemical Behavior of N-Substituted-4-Piperidones Curcumin Analogs: A Combined Experimental and Theoretical Approach, Int. J. Mol. Sci. 2022, 23(23), 15043; https://doi.org/10.3390/ijms232315043
- 5. V. Saravanan, P. Lakshmanan, N. Palanisami, John Amalraj, Radha D. Pyarasani, C. Ramalingan.2D/3D- C3N4/CeO2 S-scheme heterojunctions with enhanced photocatalytic performance. Inorg. Chem. Commun.146 (2022) 110189. https://doi.org/10.1016/j.inoche.2022.110189
- 6. Yaneris Mirabal-Gallardo, Maria del Pilar Caramantin Soriano, Verónica Rachel Olate, Luis Guzmán Jofré, Hou Yi Huang, Radha D. Pyarasani, Amalraj John, Felipe Laurie. Characterization of five Chilean agribusiness by-products and their potential use as food supplements. Emirates Journal of Food and Agriculture. 2021. 33(7): 607-612. https://doi: 10.9755/ejfa.2021.v33.i7.2730
- 7. Samira Hozhabr Araghi, Amalraj John*, Mohammad Sadegh Sadeghi Googheri, A molecular dynamics simulations study of the ionic liquid effect on the ß-glucosidase active site interactions with a flavonoid glycoside, J. Mol. Liquids. 2021 https://doi.org/10.1016/j.molliq.2021.117115
- 8. Samira Hozhabr Araghi, Amalraj John*, Mohammad Sadegh Sadeghi Googheri, How a crosslinker agent interacts with the ß-glucosidase enzyme surface in an aqueous solution: Insight from quantum mechanics calculations and molecular dynamics simulations, Colloids and Surfaces B: 203, 2021, 111761. https://doi.org/10.1016/j.colsurfb.2021.111761
- 9. T. Jayaramudu, Radha D. Pyarasani, Ali A-Fakhrabadi, Diana A-Milan, John Amalraj* Synthesis of gum acacia capped polyaniline-based nanocomposite hydrogel for the removal of methylene blue dye, Journal of Polymers and the Environment 29, 2021, 2447-2462. https://doi.org/10.1007/s10924-021-02066-w
- 10. T. Jayaramudu, K. Varaprasad, Radha D. Pyarasani, K. Koteshwara Reddy, A. Akbari-Fakhrabadi, Verónica Carrasco-Sánchez, John Amalraj* Hydroxypropyl methylcellulose-copper nanoparticle and its nanocomposite hydrogel films for antibacterial application. Carbohydrate Polymers, 254 (2021) 117302. https://doi.org/10.1016/j.carbpol.2020.117302
- 11. Anteneh F. Baye, Richard Appiah-Ntiamoah, John Amalraj, K. Koteshwara Reddy, Hern Kim Graphene oxide interlayered Ga-doped FeSe2 nanorod: A robust nanocomposite with ideal electronic structure for electrochemical dopamine detection. Electrochimica acta 363, 2020, 137245. https://doi.org/10.1016/j.electacta.2020.137245
- 12. K. Koteshwara Reddy, Harshad Bandal, Moru Satyanarayana, Kotagiri Yugender Goud,Kauveri Vengatajalabathy Gobi, Tippabattini Jayaramudu, John Amalraj,and Hern Kim. Recent Trends in Electrochemical Sensors for VitalBiomedical Markers Using Hybrid Nanostructured Materials. Advanced Science. 2020 https://doi.org/10.1002/advs.201902980
- 13. C. Rathore, N. Upadhyay, R. Kaundal, R. P. Dwivedi, S. Rahatekar, A. John, K. Dua, Murtaza M. Tambuwala, S. Jain, D. Chaudari [&] P. Negi. Enhanced oral bioavailability and hepatoprotective activity of thymoquinone in the form of phospholipidic nano-constructs Expert opinion on drug delivery 17, 2020, 237-253. https://doi.org/10.1080/17425247.2020.1716728
- 14. T. Jayaramudu, K. Varaprasad, K. Koteshwara reddy, Radha D. Pyarasani, Ali Akbari-Fakhrabadid, A. John, Chitosan-Pluronic based Cu Nanocomposite Hydrogels for Prototype Antimicrobial Applications International Journal of Biological Macromolecules 2020,143, 825-832. https://doi.org/10.1016/j.ijbiomac.2019.09.143
- 15. Oscar Valdés, Adolfo Marican, Fabian Avila-Salas, Ricardo I. Castrod,, Yaneris Mirabal, John Amalraj ,Diana Abril, Esteban F. Durán-Lara, Leonardo S. Santos. Simple approach for cleaning up 2,4,6-trichloroanisole from alcoholic-beverage-reconstituted solutions using polymeric materials. Australian Journal of Grape and Wine Research. 2019 25, 327–337. https://doi.org/10.1111/ajgw.12396
- 16. T. Jayaramudu, K. Varaprasad, Sadiku ER, John Amalraj, Temperature-sensitive semi-IPN composite hydrogels for antibacterial applications Colloids and Surface A: 2019, 572, 307-316. https://doi.org/10.1016/j.colsurfa.2019.04.012
- 17. T. Jayaramudu, K. Varaprasad, Radha D. Pyarasani, K. Koteshwara Reddy, K. Dileep Kumar, A. Akbari-Fakhrabadi, R.V. Mangalaraja, John Amalraj Chitosan capped copper oxide/copper nanoparticles encapsulated microbial resistant nanocomposite films International Journal of Biological Macromolecules 128 (2019) 499–508. https://doi.org/10.1016/j.ijbiomac.2019.01.145
- 18. Radha D. Pyarasani, Jayaramudu T, John A. Polyaniline-based conducting hydrogels. J. Mater. Sci., 54 (2019)974-996. https://doi.org/10.1007/s10853-018-2977-x
- 19. Oscar V, Adolfo M, Fabian A-S, Ricardo IS, John A, V. Felipe L, Leonardo SS, Polyaniline based materials as response to eliminate haloanisoles in spirits beverages, Ind. Engg. Chem. Res., 57 (2018) 8308-8318. https://doi.org/10.1021/acs.iecr.8b01139
- 20. Jayaramudu T, Varaprasad K, Raghavendra GM, Sadiku ER, Mohana Raju K, John A, Green synthesis of tea Ag nanocomposite hydrogels via mint leaf extraction for effective antibacterial activity. J. Biomater. Sci. Polym. Ed. 28, (2017) 1588-1602. http://dx.doi.org/10.1080/09205063.2017.1338501
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Dr. Ramiro Araya-Maturana
Perfil
Nuestra línea de investigación está enfocada en el diseño y síntesis de nuevas moléculas dirigidas a las mitocondrias, con actividad antitumoral y/o antiplaquetaria. Así como a la búsqueda de nuevas metodologías sintéticas, con especial énfasis en química verde, y del estudio experimental y teórico de la reactividad de las moléculas obtenidas.
Formación Profesional
- Químico/Lic. En Química Universidad de Chile
- Doctor en Ciencias Exactas mención Química P. Universidad Católica de Chile
Líneas de Investigación
Proyectos Vigentes
Como Director:
- 2022-2024 ““MiBi: interdisciplinary group on mitochondrial targeting and bioenergetics”” Concurso Anillos Regular de Investigación en Ciencia y/o Tecnología ACT210097
- 2022-2025 ““Advancing in developing new therapeutic agents for cáncer metástasis: synthesis and migrastatic effect of inhibitors of mitocondrial respiration on triple negative cáncer cells”” FONDECYT 1221874.
- 2022-2025 ““Synthesis of ortho-carbonyl hydroquinone derivatives that block mitochondrial bioenergetics as a novel antiplatelet strategy for thrombosis prevention without increasing bleeding risk””
Publicaciones
- Putting the brakes on tumorigenesis with snake venom toxins: New molecular insights for cancer drug Discovery. Félix A. Urra, Ramiro Araya-Maturana. Seminars in Cancer Biology 80 (2022) 195–204.
- Study of the Electrochemical Behavior of N-Substituted-4-Piperidones Curcumin Analogs: A Combined Experimental and Theoretical Approach. John Amalraj, Claudia E. Vergara, Matías Monroy-Cárdenas, Ramiro Araya-Maturana, Maximiliano Martínez-Cifuentes. Int. J. Mol. Sci. 2022, 23, 15043.
- An In Vitro and In Silico Study of Antioxidant Properties of Curcuminoid N-alkylpyridinium Salts: Initial Assessment of Their Antitumoral Properties. Oscar Forero-Doria, Luis Guzmán, Felipe Jiménez-Aspee, Javier Echeverría, Sergio Wehinger, Claudio Valenzuela, Ramiro Araya-Maturana, Maximiliano Martínez-Cifuentes. Antioxidants, 2022, 11, 1104.
- FRI-1 Is an Anti-Cancer Isoquinolinequinone That Inhibits the Mitochondrial Bioenergetics and Blocks Metabolic Shifts by Redox Disruption in Breast Cancer Cells. Miguel Córdova-Delgado, Sebastián Fuentes-Retamal, Charlotte Palominos, Camila López-Torres, Daniela Guzmán-Rivera, Oney Ramírez-Rodríguez, Ramiro Araya-Maturana, Félix A. Urra. Antioxidants 2021, 10, 1618.
- Synthesis and pharmacological evaluation of acylhydroquinone derivatives as potent antiplatelet agents. Diego Méndez, Viviana Donoso-Bustamante, Juan Pablo Millas-Vargas, Hernán Pessoa-Mahana, Ramiro Araya-Maturana, Eduardo Fuentes. Biochemical Pharmacology 183 (2021) 114341.
- An Experimental and Theoretical Study of Dye Properties of Thiophenyl Derivatives of 2-Hydroxy-1,4-naphthoquinone (Lawsone). Matías Monroy-Cárdenas, Oscar Forero-Doria, Ramiro Araya-Maturana, Maximiliano Martínez-Cifuentes. Materials 2021, 14, 5587.
- An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells. Viviana Donoso-Bustamantea, Edgar A. Borrego, Yareli Schiaffino-Bustamante, Denisse A. Gutiérrez, Juan Pablo Millas-Vargas, Sebastián Fuentes-Retamal, Pablo Correa, Ileana Carrillo, Renato J. Aguilera, Dante Miranda, Ignacio Chávez-Báez, Rodrigo Pulgare, Félix A. Urra, Armando Varela-Ramírez, Ramiro Araya-Maturana. Bioorganic Chemistry 100 (2020) 103935.
- Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6. Diego Méndez, Félix A. Urra, Juan Pablo Millas-Vargas, Marcelo Alarcón, Julio Rodríguez-Lavado, Iván Palomo, Andrés Trostchansky, Ramiro Araya-Maturana, Eduardo Fuentes. European Journal of Medicinal Chemistry 192 (2020) 112187.
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Dra. Margarita Isabel Gutiérrez Cabrera
Formación Profesional
- Licenciada en Biología, Universidad de Talca
- Doctor en Ciencias mencion Investigación y Desarrollo de Productos Bioactivos
Líneas de Investigación
Proyectos Vigentes
Laboratorio de Sintesis Organica y actividad Biologica:
Sintesis, purificacion y caracterizacion espectroscopica de heterociclos nitrogenados y evaluacion de su actividad biologica.
Publicaciones
• Semisynthesis, Characterization and Evaluation ofNew Adenosine Derivatives asAntiproliferative Agents. Francisco Valdés Zurita, Nelson Brown Vega and Margarita Gutiérrez Cabrera. Molecules 2018, 23, 1111; doi:10.3390/molecules23051111.
• Design, facile synthesis, and evaluation of novel spiro and pyrazolo [1,5-c] quinazolines as cholinesterase inhibitors: Molecular docking and MM/GBSA studies.Jaime Gálvez, StivensPolo, Braulio Insuasty, Margarita Gutiérrez, Daniela Cáceres, JansH. Alzate-Morales, Pedro De-la-Torre, Jairo Quiroga. Computational Biology and Chemistry, 2018, 74, 218–229. https://doi.org/10.1016/j.compbiolchem.2018.03.001.
• Synthesis of novel 7-aryl and 7-spiropyrazolo[4_,3_:5,6]pyrido[2,3-d]pyrimidine derivatives and their study as AChE inhibitors. Paola Acosta, Braulio Insuasty, Rodrigo Abonia, Margarita Gutierrez, Jairo Quiroga. Mol Divers2017, 21:943–955. DOI 10.1007/s11030-017-9774-3.
• Microwave-assisted one-pot synthesis in water ofcarbonylpyrazolo[3,4-b]pyridine derivatives catalyzed by InCl3 and sonochemical assisted condensation with aldehydes to obtain new chalcone derivatives containing the pyrazolopyridinic moiety. Efrain Polo, Karoll Ferrer-Pertuz, Jorge Trilleras, Jairo Quiroga and Margarita Gutierrez. RSC Adv., 2017, 7, 50044. DOI: 10.1039/c7ra10127a.
• N-{4-[(2E)-3-(2H-1,3-Benzodioxol-5-yl)prop-2- enoyl]phenyl}quinoline-3-carboxamide. Efrain Polo, Jorge Trillerasand Margarita Gutiérrez Cabrera. Molbank, 2017, M960; doi:10.3390/M960.
• Production of Secondary Metabolites by Immobilized Cells of Stereocaulon ramulosum (Sw) Rausch (lichen) in Different Design of Bioreactors Iris Pereira , Eugenia C Pereira and Margarita Gutiérrez. Journal of Chemical and Pharmaceutical Research, 2017, 9(5):104-109.
• Synthesis of New (E)-2-(1H-Indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles via Microwave-Assisted Knoevenagel Condensation. Adriana V. Treuer, Pedro De-La-Torre, and Margarita I. Gutiérrez. Hindawi Journal of Chemistry, Volume,2017, Article ID 8418930, 8 pages https://doi.org/10.1155/2017/8418930.
• Efficient MW-Assisted Synthesis, Spectroscopic Characterization, X-ray and Antioxidant Properties of Indazole Derivatives. Efrain Polo, Jorge Trilleras, Juan Ramos, Antonio Galdámez, Jairo Quiroga and Margarita Gutiérrez. Molecules, 2016, 21, 903; doi:10.3390/molecules21070903.
• Novel N-allyl/propargyltetrahydroquinolines: Synthesis via Three-component Cationic Imino Diels–Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors. Yeray A.Rodríguez, Margarita Gutiérrez, David Ramırez, JansAlzate-Morales, Cristian C. Bernal, Fausto M. Guiza and Arnold R. Romero Bohórquez. ChemBiolDrug Des2016; 88: 498–510.
• Chemicalcomposition and antibacterial activity of essential oils from Azorellaspinosa(apiaceae) against wild phytopathogenic bacteria .Adriana Jara-Bermeo, Patricio Peñailillo, Aurelio San-Martín, Omar Malagón,GianlucaGilardoni, Margarita Gutiérrez. J. Chil. Chem. Soc., 2016,61 (4).
• Exploring coumarin potentialities: development of new MAO-B inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold. Fernanda Borges, Eugenio Uriarte, Lourdes Santana, Andre Fonseca, María Joao Matos, Joana Reis, Margarita Gutiérrez, Yorley Duarte. RSC Advances . 2016. DOI: 10.1039/C6RA05262B.
• Synthesis and insilicoanalysisofthequantitative structure activityrelationshipofheteroaryl–acrylonitrilesasAChEinhibitors. Pedro De la Torre, Adriana V. Treuer, Margarita Gutierrez, Horacio Poblete, Jans H. Alzate Morales, Jorge Trilleras, Luis Astudillo Saavedra, Julio Caballero. Journal of the Taiwan Institute of Chemical Engineers,2016. 59, 45–60. http://dx.doi.org/10.1016/j.jtice.2015.07.022.
• Monitoring and mechanisms of organophosphate resistance inSan Jose scale, Diaspidiotusperniciosus (Hemiptera:Diaspididae). K. A. Buzzetti, R. A. Chorbadjian, E. Fuentes-Contreras, M. Gutierrez, J. C. Rıos and R. Nauen. J. Appl. Entomol.2016, 140, 507–516. doi: 10.1111/jen.12283.
• Crystal structure of (E)-2-(benzo[d]thiazol-2-yl)-3- (pyridin-3-yl)acrylonitrile). Pedro De-La-Torre, Margarita Gutierrez, Julio Caballero, Jorge Trilleras, Luis Astudillo,Alejandro Cárdenas and Iván Brito. Z. Kristallogr. NCS 2016; 231(1): 171–173.
• DihydroagarofuranoidSesquiterpenes as Acetylcholinesterase Inhibitors from Celastraceae Plants: Maytenusdisticha and Euonymus japonicas. Julio Alarcón,Carlos L. Cespedes,Evelyn Muñoz,Cristian Balbontin, Francisco Valdes, Margarita Gutierrez,Luis Astudillo,and David S. Seigler. J. Agric. Food Chem.2015, 63, 10250−10256. DOI: 10.1021/acs.jafc.5b04168.
• Tetrahydroquinolines and Isoxazoles: Nitrogen heterocycles as potential antibacterial agents. Yorley Duarte, Fernando Dueñas and Margarita Gutiérrez. Journal of Chemical and Pharmaceutical Research, 2015, 7(3):294-299.
• Docking's study of 6-substituted adenosine-5'-N-ethyluronamide analogs as selective agonists at A3 adenosine receptor and selection of compounds for to be synthesized later. Francisco Valdés, Z. Víctor Luna, Bárbara Arévalo, Margarita Gutierrez. Der Pharma Chemica, 2015, 7(6):212-225.
• Theantioxidant and antibacterialactivity of Azorellamultifidaonphytopathogenic bacteria. Jefferson Romero, Adriana Jara,Maria Elena Cazar, Aurelio San Martin and Margarita Gutierrez. Journal of Chemical and Pharmaceutical Research, 2015, 7(7):1194-1198.
• Nano-Detoxification of Organophosphate Agents by PAMAM Derivatives. Esteban F. Durán-Lara, Fabian Ávila-Salas, Sebastian Galaz, Amalraj John, Adolfo Maricán, Margarita Gutiérrez, Fabiane M. Nachtigall, Fernando D. Gonzalez-Nilo and Leonardo S. Santos. J. Braz. Chem. Soc., Vol. 26, No. 3, 580-591, 2015. http://dx.doi.org/10.5935/0103-5053.20150013.
• Molecular Docking Studies of the Antitumoral Activity and Characterization of New Chalcone. Aurelio San-Martin, Viviana Donoso, Sergio Leiva, Mitchell Bacho, Solange Nunez, Margarita Gutierrez, Juana Rovirosa, Natalia Bailon-Moscoso, Sandra Cuenca Camacho, Omar Malagon Aviles and Maria-Elena Cazar Pages 1743 - 1749 (7). Current Topics in Medicinal Chemistry. 2015. DOI : 10.2174/1568026615666150427125033.
• Synthesis, molecular docking and design of Tetrahydroquinolines as acetylcholinesterase inhibitors. Margarita Gutiérrez, Bárbara Arévalo, Gonzalo Martínez, Francisco Valdés, Gabriel Vallejos, Unai Carmona and Aurelio San Martin. Journal of Chemical and Pharmaceutical Research, 2015, 7(3):351-358.
• Molecular Docking Studies of the Antitumoral Activity and Characterization of New Chalcone. Aurelio San-Martín, Viviana Donoso, Sergio Leiva, Mitchell Bacho, Solange Núñez, Margarita Gutierrez, Juana Rovirosa, Natalia Bailón-Moscoso, Sandra Cuenca Camacho, Omar Malagón Aviles and María-Elena Cazar. Current Topics in Medicinal Chemistry, 2015, 15, 1743-1749.
• Nano-Detoxification of Organophosphate Agents by PAMAM Derivatives Esteban F. Durán-Lara, Fabian Ávila-Salas, Sebastian Galaz, Amalraj John, Adolfo Maricán, Margarita Gutiérrez, Fabiane M. Nachtigall, Fernando D. Gonzalez-Nilo and Leonardo S. Santos. J. Braz. Chem. Soc., Vol. 00, No. 00, 1-12, 2015.
• Monitoring and mechanisms of organophosphate resistance in San Jose scale, Diaspidiotus perniciosus (Hemiptera: Diaspididae). K Buzzetti, R A Chorbadjian, E Fuentes-Contreras, M Gutiérrez, JC Ríos and R Nauen. Journal of Applied Entomology doi: 10.1111/jen.12283
• Dihydroagarofuranoid Sesquiterpenes as Acetylcholinesterase Inhibitor from Celastraceae Plants: Maytenus disticha and Euonymus japonicus.Julio Alarcon, Carlos L Cespedes, Evelyn Muñoz, Cristian Balbontin, Francisco Valdes, Margarita Gutierrez, Luis Astudillo, and David Seigler. J. Agric. Food Chem. 2015, 63, 10250−10256
• Antifungal and Insecticidal properties of the Phytoconstituents of Drimys winteri (Winteraceae) growing in Chiloe Island (Chile). Muñoz O, Gutierrez M, Gonzalez R, Hammann S and Vetter W. Nat Prod Chem Res 2015, 3:182. http://dx.doi.org/10.4172/2329-6836.1000182.
• Crystal structure of (E)-2-(Benzo[d]thiazol-2-yl)-3-(pyridin-3-yl) acrylonitrile). Pedro De-La-Torre, Margarita Gutierrez, Julio Caballero, Jorge Trilleras, Luis Astudillo, Alejandro Cardenas and Ivan Brito. Zeitschrift für Kristallographie - New Crystal Structures. Volume 231, Issue 1, Pages 171–173, ISSN (Online) 2197-4578, ISSN (Print) 1433-7266, DOI: 10.1515/ncrs-2015-0073, January 2016.
• Synthesis and in silico analysis of the quantitative structure activity relationship of heteroaryl–acrylonitriles as AChE inhibitors. Pedro De-la Torre, AdrianaV.Treuer, Margarita Gutierrez, Horacio Poblete, Jans H.Alzate-Morales, JorgeTrilleras, Luis Astudillo-Saavedra, Julio Caballero. Journal of the Taiwan Institute of Chemical Engineers 59 (2016) 45–60
• Exploring coumarin potentialities: development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold A. Fonseca, M. J. Matos, J. Reis, Y. Duarte, M. Gutierrez, L. Santana, E. Uriarte and F.Borges. RSC Adv., 2016, DOI: 10.1039/C6RA05262B.
• Novel N-allyl/propargyl tetrahydroquinolines: Synthesis via Three-component Cationic Imino Diels–Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors. Yeray A. Rodrıguez, Margarita Gutierrez, David Ramırez, Jans Alzate-Morales, Cristian C. Bernal, Fausto M. Guiza and Arnold R. Romero Bohorquez. Chem Biol Drug Des. (Aceptado) 2016.
• Efficient MW-assisted synthesis, spectroscopic characterization, X-ray and antioxidant properties of pyrazole derivatives. Efrain Polo, Jorge Trilleras, Juan Ramos, Antonio Galdamez, Jairo Quiroga, Margarita Gutierrez. Molecules. doi:10.3390/molecules21070903
×
Dr. Leonardo S. Santos
Perfil
Prof. Dr. Leonardo S. Santos es profesor de plenos en la Universidad de Talca. Es un científico reconocido internacionalmente con experiencia que abarca los campos de Química Orgánica, Espectrometría de Masas, Agrícola, incluyendo tecnología de omics, nanomedicina, descubrimiento de fármacos y nuevas tecnologías clínicas analíticas. Anteriormente fue Director de la División de Nanobiotecnología de la Investigación Fraunhofer Chile (2010-2017), y Doctorado en el Instituto de Química de Investigación Natural de la Universidad de Talca, Chile (2012-2023).
Líneas de Investigación
Publicaciones
--- 2024 ---
Mesías-Salazar, A., Rojas, R. S., Carrillo-Hermosilla, F., Martinez, J., Antiñolo, A., Trofymchuk, O. S., Nachtigall, F. M., Santos, L. S., Daniliuc, C. G. "Guanidinium Iodide Salts as Single Component Catalysts in CO2 to Epoxide Fixation" New J. Chem. 2024, 48, 105-111. https://doi.org/10.1039/D3NJ03959E
Fonseca-Lopez, D., Ezenarro-Salcedo, D., Nachtigall, F. M., Santos, L. S., Macias, M., Rojas, R., Hurtado, J. "Air-stable Cobalt(II) and Chromium(III) Complexes as Single-component Catalysts for the Activation of CO2 and Epoxides" Inorg. Chem. 2024, 63, 9066-9077. https://doi.org/10.1021/acs.inorgchem.4c00151
Reis, A. F. A., Sathish, M., Nachtigall, F. M., Santos, L. S. "Pd-Monothiosquaramides: Efficient catalysts for Enantioselective Imine Reduction of Dihidro-b-Carboline" Asian J. Org. Chem. 2024, https://doi.org/10.1002/ajoc.202400245.
Quezada, V., Castroagudin, M., Verdugo, F., Ortiz, S., Zaragoza, G., Nachtigall, F. M., Reis, F. A. A., Santos, L. S., Nelson, R. "Nickel(II)-catalyzed formal [3 + 2] cycloaddition between indoles and donnor-acceptor cyclopropanes" Molecules 2024, 29, 1604-1623. https://doi.org/10.3390/molecules29071604
Rios,E. A. M., Dea, C. M., dos Santos, E. R. F. B., D'Oca, M. G. M., Rampon, D. S., Nachtigall, F. M., Santos, L. S., Guzman, L., Moore-Carrasco, R., Rebolledo-Mira, D., D'Oca, C. R. M. "Synthesis of Novel Fatty Acid Biginelli 3,4-dihydropyrimidine-2-(1H) One-Pot and Antitumoral Activity against Breast and Gastric Cancer Cells" RSC Adv. 2024, 14, 22981-22987. https://doi.org/10.1039/D4RA03292F
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--- 2023 ---
Rojas, M. A., Amalraj, J., Santos, L. S. "Biopolymer-based composite hydrogels embedding small silver nanoparticles for advanced antimicrobial applications. Experimental and theoretical insights" Polymers 2023, 15, 3370. https://doi.org/10.3390/polym15163370
--- 2022 ---
Sathish, M., Nachtigall, F. M.,; Santos, L. S. "Enantioselective imine reduction of dihydro-β-carbolines by Fe-thiosquaramide catalyst" Org. Lett. 2022, 24(41), 7627-7631. https://doi.org/10.1021/acs.orglett.2c03093
Soni, J. P., Sathish, M., Nachtigall, F. M., Santos, L. S., Shankaraiah, N. "Brown seaweed-derived alginic acid: An efficient and reusable catalyst for Pictet-Spengler reaction to access tetrahydro-β-carboline and tetrahydroisoquinoline frameworks" Asian J. Org. Chem. 2022, 11(5), e202200129. DOI: https://doi.org/10.1002/ajoc.202200129
González, R. J., Quispe, C., Santos, L. S., Nachtigall, F. M. "Detection of Organic Gunshot Residues from human hands using DSA-TOF" J. Mass Spectrom. 2022, 57(5), e4824. DOI: https://doi.org/10.1002/jms.4824
Morales-Quintana, L., Bustos, D., Gallego, J., Valdes, O., Guzmán, L., Nachtigall, F. M., Marican, A., Hernández-Rodríguez,E. W., Ávila-Salas, F., Bueno-Silva, W., Santos, L. S., Castro, R. I. "Physicochemical and computational analysis of the melamine resin derivative for the glyphosate absorption from water using Langmuir-type model" Int. J. Environ. Sci. Technol. 2022, 19, 7791-7802. DOI: https://doi.org/10.1007/s13762-021-03685-5.
Kahlaoui, B., Sánchez-Contreras, J., Santos, L. S., Misle, E., Yuri, J. "Assessing apple coming from agroclimatic differing locations: a tool for evaluating impact of environmental variation on postharvest" N. Z. J. Crop Hortic. Sci. 2022, ASAP. DOI: https://doi.org/10.1080/01140671.2022.2135543
--- 2021 ---
Hernández-Olivos, R., Muñoz, M., Núñez, Camargo-Ayala, P. A., Garcia-Huidobro, J., Pereira, A.,Nachtigall,F. M., Santos, L. S., Rivera, C. "Salivary proteome of aphthous stomatitis reveals the participation of vitamin metabolism, nutrients, and bacteria" Scientific Rep. 2021, 11, 15646. DOI: https://doi.org/10.1038/s41598-021-95228-8
Sathish, M., Sakla,A. P., Nachtigall, F. M., Santos, L. S., Shankaraiah, N. "TCCA-mediated oxidative rearrangement of tetrahydro-β-carbolines: facile access to spirooxindoles and the total synthesis of (±)-coerulescine and (±)-horsfiline" RSC Adv. 2021,11, 16537-16546. DOI: https://doi.org/10.1039/D1RA02381K
Trofymchuk, O. S., Ortega, D. E., Cortés-Arriagada, D., Pereira, A., Daniliuc, C. G., Klitzke, C. F., Santos, L. S., Rojas, R. S. "Neutral and cationic methallyl nickel complexes in alkene activation: a combined DFT, ESI-MS and chemometric approach" Catal. Sci. Technol., 2021, 11, 7475-7485. DOI: https://doi.org/10.1039/D1CY01595H
Verónica R Olate-Olave, V. R.; Guzmán, L.; López-Cortés, X. A.; Cornejo; R.; Nachtigall, F. M.; Doorn, M.; Santos, L. S.; Bejarano, A. "Comparison of Chilean honeys through MALDI-TOF-MS profiling and evaluation of their antioxidant and antibacterial potential" Ann. Agric. Sci. 2021, 66, 152-161. DOI: https://doi.org/10.1016/j.aoas.2021.11.001
--- 2020 ---
Nachtigall, F. M., Pereira, A., Trofymchuk, O. S., Santos, L. S. "Detection of SARS-CoV-2 in nasal swabs using MALDI-MS¨ Nature Biotechnol. 2020, 38, 1168-1173. DOI: 10.1038/s41587-020-0644-7.
Sathish, M., Nachtigall, F. M., Santos, L. S. "Bifunctional Thiosquaramide Catalyzed Asymmetric Re-duction of Dihydro-β-carbolines and Enantioselective Synthesis of (–)-Coerulescine and (–)-Horsfiline by Oxida-tive Rearrangement" RSC Adv. 2020, 10, 38672–38677. DOI: 10.1039/d0ra07705d
Porciuncula, L. M., Teixeira, A. R., Santos, M. F. C., D’Oca, M. G. M., Santos, L. S., F. M. Nachtigall, Orth, E. S., D’Oca, C. R. M. "Novel lipophilic analogues from 2,4-D and Propanil
herbicides: Biological activity and kinetic studies" Chem. Phys. Lipids 2020, 231, 104947. DOI: 10.1016/j.chemphyslip.2020.104947.
Ortega, D.; Cortés-Arriagada, D.; Trofymchuk, O. S.; Nachtigall, F. M.; Santos, L. S.; Rojas, R.; Toro-Labbé, A. "Mechanistic study of the competitiveness between branched and linear polyethylene production on N-arylcyano-β-diketiminate nickel hydride¨ Polym. Chem. 2020, 11, 6640-6649. DOI: 10.1039/D0PY01027H.
Monsalve, F., Delgado-Lopez, F., Rojas, A., Perez-Castro, R., Anazco, C., Romero, J., Araya, P., Santos, L. S., Gonzalez, I. "RID: Evaluation of the Possible Inhibiting Effect of the Proinflammatory Signaling Induced by TNF-α through NF-κβ and AP-1 in Two Cell Lines of Breast Cancer" Mediators of Inflammation 2020, 2707635. DOI: 10.1155/2020/2707635
Contreras, J., Valdés, O., Mirabal-Gallardo, Y., de la Torre, A. F., Navarrete, J., Lisperguer, J., Durán-Lara, E. F., Santos, L. S., Nachtigall, F. M., Cabrera-Barjas, G., Abril, D., "Development of eco-friendly polyurethane foams based on Lesquerellafendleri (A. Grey) oil-based polyol” Eur. Pol. J. 2020, 128, 109606. DOI: 10.1016/j.eurpolymj.2020.109606
Mesias-Salazar, A., Trofymchuk, O. S., Daniliuc, C. G., Antiñolo, A., Hermosilla, F. C., Nachtigall, F. M., Santos, L. S., Rojas, R. "Copper (II) as Catalyst for Intramolecular Cyclization and Oxidation of (1,4-phenylene)bisguanidines to Benzodiimidazole-diylidenes¨ J. Catal. 2020, 382, 150-154. DOI: 10.1016/j.jcat.2019.12.002
Rocca, M. F., Zintgraff, J. C., Dattero, M. E., Santos, L. S., Ledesma, M., Vay, C., Prieto, M., Benedetti, E., Avaro, M., Russo, M., Nachtigall, F. M., Baumeister, E. "A combined approach of MALDI-TOF Mass Spectrometry and multivariate analysis as a potential tool for the detection of SARS-CoV-2 virus in nasopharyngeal swabs¨ J. Virol. Methods 2020, 286, 113991. DOI: 10.1016/j.jviromet.2020.113991
Vidal, V. A. S., Nachtigall, F. M., Baseggio, A., Junior, M. R. M., Santos, L. S., Pollonio, M. A. R. “How Does Reducing Sodium Impact the Proteolysis and Texture in Salted Meat Along 180 Days of Shelf Life?” Emirates J. Food Agric. 2020, 32, 653-7, DOI: 10.9755/ejfa.2020.
--- 2019 ---
Abril, D., Mirabal-Gallardo, Y., González, A., Marican, A., Durán-Lara, E. F., Santos, L. S., Valdés, O. "Comparison of the Oxidative Stability and Antioxidant Activity of Extra-Virgin Olive Oil and Oils Extracted from Seeds of Colliguaya integerrima and Cynara cardunculus under Normal Conditions and After Thermal Treatment” Antioxidants 2019, 8, 470-485. DOI: 10.3390/antiox8100470
Nachtigall, F. M., Vidal, V. A. S., Pyarasani, R. D., Dominguez, R., Lorenzo, J. M., Santos, L. S., Pollonio, M. A. R. "Substitution effects of NaCl by KCl and CaCl2 on lipolysis of salted meat” Foods 2019, 8, 595-614. DOI: 10.3390/foods8120595
Tokala, R.; Bora, D.; Sana, S.; Nachtigall, F. M.; Santos, L. S.; Shankaraiah, N. "Ru(II)-catalyzed regioselective hydroxymethylation of β-carbolines and isoquinolines via C-H functionalization: Probing the mechanism by online ESI-MS/MS screening” J. Org. Chem. 2019, 84, 5504−5513. DOI: 10.1021/acs.joc.9b00454.
Valdes, O., Marican, A., Avila-Salas, F., Castro, R. I., Mirabal, Y., Amalraj, J., Abril, D.,, Duran-Lara, E., Santos, L. S. "Simple approach for cleaning up 2,4,6-trichloroanisole from alcoholic-beverage-reconstituted solutions using polymeric materials” Australian J. Grape Wine Res. 2019, 25, 327-337. DOI: 10.1111/ajgw.12396.
Shankaraiah, N., Kumar, N. P., Tokala, R., Gayatri, B. S., Talla, V., Santos, L. S. "Synthesis of new 1,2,3-triazolo-naphthalimide/phthalimide conjugates via ‘click’ reaction: DNA intercalation and cytotoxic studies” J. Braz. Chem. Soc. 2019, 30, 454-461.
Nuñez, Y. A. R., Castro, R. I., Arenas, F. A., López-Cabaña, Z. E., Carreño, G., Carrasco-Sánchez, V., Marican, A., Villaseñor, J., Vargas, E., Santos, L. S., Durán-LaraSantos, E. F. "Preparation of hydrogel/silver nanohybrids mediated by tunable-size silver nanoparticles for potential antibacterial applications” Polymers 2019, 11, 716. DOI: 10.3390/polym11040716.
--- 2018 ---
Forero-Doria, O., Castro, R., Gutierrez, M., Gonzalez-Valenzuela, D., Santos, L. S., Ramirez, D., Guzman, L. "Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections” Molecules 2018, 23, 2354-2368.
Avila-Salas, F. ,Rodriguez Nuñez, Y. A., Marican, A., Castro, R. I., Villaseñor, J., Santos, L. S., Wehinger, S., Durán-Lara, E. F. "Rational Development of a Novel Hydrogel as a pH-Sensitive Controlled Release System for Nifedipine” Polymers 2018, 10, 806.
Nachtigall, F. M., Rojas, M., Santos, L.S. "MALDI coupled to modified Traveling-Wave Ion-Mobility Mass Spectrometry for fast enantiomeric determination” J. Mass Spectrom. 2018, 53, 693-699.
Valdés, O., Marican, A., Mirabal, Y., Santos, L.S. "Selective and efficient Arsenic recovery from water through quaternary amino-functionalized silica” Polymers 2018, 10, 626.
Valdés, O., Marican, A., Avila-Salas, F., Castro, R. I., Amalraj, J., Laurie, V. F., Santos, L.S. "Polyaniline based materials as response to eliminate haloanisoles in spirits beverages” Ind. Eng. Chem. Res. 2018, 57, 8308–8318.
Duran-Lara, E.D., da Silva, W.A., Guzman, L., Castro, R., Andrade, C.K.Z, Santos, L.S. "Inhibition of IL-2 production by novel small molecules using building blocks from reduced chalcones and a substituted proline” Curr. Drug Therapy 2018, 13, 130-139.
Escobar, M.A., da Costa, D.M., Trofymchuk, O.S., Daniliuc, C.G., Gracia, F., Nachtigall, F.M., Santos, L.S., Rojas, R.S., Cabrera, A.R. "Intermolecular stabilization in new 2-iminopyridine derivatives complexes of Pd(II) and their reactivity towards alkenes” J. Organomet. Chem. 2018, 863, 21-29.
--- 2017 ---
Gil, M., Avila-Salas, F., Santos, L. S., Iturmendi, N., Moine, M., Cheynier, V., Saucier, C. "Rosé wine fining using polyvinylpolypyrrolidone: Colorimetry, targeted polyphenomics and molecular dynamics simulations" J. Agric. Food. Chem. 2017, 65, 10591–10597.
Forero-Doria, O., Shankaraiah, N., Nachtigall, F. M., Santos, L. S. "Polymer-supported (-)-8-phenylmenthyl auxiliary as an effective solid-phase chiral inductor in the addition of nucleophiles to N-acyliminium ions" Comb. Chem. High Throughput Screen. 2017, 20, 696-702.
Donoso, W., Castro, R. I., Guzman, L., López-Cabaña, Z., Nachtigall, F. M., Santos, L. S. "Fast Detection of Listeria monocytogenes through nanohybrid quantum dot complex" Anal. Bioanal. Chem. 2017, 409, 5359-5371.
Nachtigall, F. M., Santos, L. S. "On-bed MALDI-MS monitoring of solid-supported N-acyliminium ion reactions" J. Mass Spectrom. 2017, 52, 254-258.
López-Cortés, X. A., Nachtigall, F. M., Olate, V. R., Araya, M., Oyanede, S., Diaz, V., Jakob, E., Ríos-Momberg, M., Santos, L. S. "Fast detection of pathogens in salmon farming industry" Aquaculture 2017, 470, 17-24.
D`Oca, C. R. M.; Naciuk, F. F., Silva, J. C., Guedes, E. P., Moro, C. C., D`Oca, M. G. M., Santos, L. S., Nachtigall, F. M., Russowsky, D. "New Multicomponent Reaction for the Direct Synthesis of b-Aryl-g-nitroesters Promoted by Hydrotalcite-Derived Mixed Oxides as Heterogeneous Catalyst" J. Braz. Chem. Soc. 2017, 28, 285-298.
Vergara-Jaque, A., Comer, J., Sepúlveda-Boza, S., Santos, L. S., Mascayano, C., Sandova-Yáñez, C. "Study of Specific Interactionsin Inclusion Complexes of Amine-Terminated PAMAM Dendrimer/Flavonoids by Experimental and Computational Methods" Int. J. Polym. Mat. Polym. Biomat. 2017, 66, 485-494.
Sharma, P., Kumar, N. P., Senwar, K. R., Forero-Doria, O., Nachtigall, F. M., Santos, L. S., Shankaraiah, N. "Effect of Sulfamic Acid on 1,3-Dipolar Cycloaddition Reaction: Mechanistic Studies and Synthesis of 4-Aryl-NH-1,2,3-triazoles from Nitroolefins" J. Braz. Chem. Soc. 2017, 28, 589-597.
--- 2016 ---
D`Oca, C. R. M, da Silva, J. C., Guedes, E. P, D`Oca, M. G. M., Santos, L. S., Nachtigall, F. M., Russowsky, D. "A new multicomponent reaction for direct synthesis of primary gama-nitroamides" RSC Adv. 2016, 6, 98427-98433.
Castro, R. I., Forero-Doria, O., Guzman, L., Laurie, V. F., Valdes, O., Avila-Salas, F., Lopez-Cortes, X., Santos, L. S. "New polymer for removal of wine phenolics: poly(N-(3-(N-isobutyrylisobutyroamido)-3-oxopropyl)acrylamide) (P-NIOA)" Food Chem. 2016, 213, 554-560.
Nekkanti, S., Kumar, N. P., Sharma, P., Kamal, A., Nachtigall, F. M., Forero-Doria, O., Santos, L. S., Shankaraiah, N. "TBAI/TBHP-catalyzed [3 + 2]cycloaddition/oxidation/aromatization cascade and online ESI-MS mechanistic studies: synthesis of pyrrolo[2,1-a]isoquinolines and indolizino[8,7-b]indoles" RSC Adv. 2016, 6, 2671-2677.
Olate, V. R., Nachtigall, F. M., Santos, L. S., Araya, M., Oyanedel, S., Diaz, V., Marchant, V., Rios-Momberg, M. "Fast detection of Piscirickettsia salmonis in Salmo salar serum through MALDI-TOF-MS profiling" J. Mass. Spectrom. 2016, 51, 200-206.
Forero-Doria, O., Gallego, J., Valdes, O., Pinzon-Topal, C., Santos, L. S., Guzmán, L. "Relationship between oxidative stability and antioxidant activity of oil extracted from the peel of Mauritia flexuosa fruits" J. Therm. Anal. Calorim. 2016, 123, 2173-2178.
Valdes, O., Vergara, C. E., Nachtigall, F. M., Lopez-Cabaña, S., Tapia, J., Santos, L. S. "PAMAM built-on-silicon wafers thin-layer extraction devices for selective metal contamination detection" Tetrahedron Lett. 2016, 57, 2468-2473.
--- 2015 ---
Escobar, M. A., Trofymchuk, O. S., Rodriguez, B. E., Lopez-Lira, C., Tapia, R., Daniluc, C., Berke, H., Nachtigall, F. M., Santos, L. S., Rojas, R. S. "Lewis Acid Enhanced Ethene Dimerization and Alkene Isomerization - ESI-MS Identification of the Catalytically Active Pyridyldimethoxybenzimidazole Nickel(II) Hydride Species" ACS Catalysis 2015, 5, 7338-7342.
Durán-Lara, E. F., Marple, J. L., Giesen, J. A., Fang, Y., Jordan, J. H., Godbey, W. T., Marican, A., Santos, L. S., Grayson, S. M ."Investigation of Lysine-Functionalized Dendrimers as Dichlorvos Detoxification Agents" Biomacromolecules 2015, 16, 3434-3444.
Carrasco-Sánchez, V., John, A., Marican, A., Santo, L. S., Laurie, V. F. "Removal of 4-Ethylphenol and 4-Ethylguaiacol with Polyaniline-Based Compounds in Wine-Like Model Solutions and Red Wine" Molecules 2015, 20, 14312-14325.
Martínez-Cifuentes, M., Salazar, R. Escobar, C., Weiss-López, B., Santos, L.S., Araya-Maturana, R. "Correlating Experimental Electrochemistry and Theoretical Calculations in 2´-Hydroxy Chalcones Derivatives of Pharmacological Interest: The Role of Intramolecular Hydrogen Bond" RSC Advances 2015, 5, 50929-50937.
Guzman, L., Duran-Lara, E. F., Donoso, W., Nachtigall, F. M., Santos, L. S. "In vivo Nanodetoxication for acute uranium exposure" Molecules2015, 20, 11017-11033.
Martinez-Cifuentes, M., Weiss-Lopez, B., Santos, L. S., Araya-Maturana, R. "Heterocyclic Curcumin Derivatives of Pharmacological Interest: Recent Progress" Curr. Top. Med. Chem. 2015, 15, 1663-1672.
Deacon, R. M. J., Altimiras, F. J., Bazan-Leon, E. A., Pyarasani, R., Nachtigall, F. M., Santos, L. S., Tsolaki, A. G., Pednekar, L., Kishor, U., Biekofsky, R. R., Vasquez, R. A., Cogram, P. "Natural AD-like neuropathology in Octodondegus: impaired burrowing and neuroinflamation" Curr. Alzheimer Res. 2015, 12, 314-322.
Lopez-Cabana, Z., Valdes, O., Vergara, C. E., Camarada, M. B., Nachtigall, F. M., Gonzalez-Nilo, F. D., Santos, L. S. "Photophysical studies of the interactions of poly(amidoamine) generation zero (PAMAM G0) with copper and zinc ions" J. Luminescence 2015, 164, 23-30.
Duran-Lara, E., Avila-Salas, F., Galaz, S., John, A., Marican, A., Gutierrez, M., Nachtigall, F. M., Gonzalez-Nilo, F. D., Santos, L. S. "Nano-Detoxification of Methamidophos by PAMAM derivatives" J. Braz. Chem. Soc. 2015, 26, 580-591.
Valdes, O., Vergara, C.E., Camarada, M.B., Carrasco-Sánchez, V., Nachtigall, F.M., Tapia, J., Fischer, R., González-Nilo, F.D., Santos, L.S. "Synthesis and characterization of an insoluble polymer based on polyamidoamine: Applications for the decontamination of metals in aqueous systems". J. Environ. Manag. 2015, 147, 321-329.
Duran-Lara, E., Lopez-Cortes, X. A., Castro, I., Avila-Salas, F., Gonzalez-Nilo, F. D., Laurie, V. F., Santos, L. S. "Experimental and Theoretical Binding Affinity Between Polyvinylpolypyrrolidone and Selected Wine Phenolic Compounds" Food Chem. 2015, 168C, 464-470.
Soriano, M. D. P. C., Mirabal-Gallardo, Y., Carrasco-Sanchez, V., Nachtigall, F. M., Pereira, I., Pereira, E. C., Santos, L. S. "Chemotaxonomic Fingerprinting of Chilean Lichens Through MALDI and Electrospray Ionization Mass Spectrometry" Braz. Arch. Biol. Technol. 2015, 58, 244-253.
--- 2014 ---
Camarada, M. B., Zuñiga, M., Alzate-Morales, J., Santos, L. S. "Computational Study of the Complexation of Metal Ions with Poly(amidoamine) PAMAM G0 Dendrimers" Chem. Phys. Lett. 2014, 616-617, 171-177.
Martinez-Cifuentes, M., Weiss-Lopez, B., Santos, L. S., Araya-Maturana, R. "Intramolecular Hydrogen Bond in Biologically Active Carbonyl Hydroquinones" Molecules 2014, 19, 9354-9368.
Marican, A., Carrasco-Sanchez, V., John, A., Laurie, V. F. Santos, L. S. "The Binding of 4-Ethylguaiacol with Polyaniline-based Materials in Wine" Food Chem. 2014, 159, 486-492.
Schramm, O. G., López-Cortés, X., Santos, L. S., Laurie, V. F., González-Nilo, F. D., Krolik, M., Fischer, R., Di Fiore, S. "pH-dependent nano-capturing of tartaric acid using dendrimers" Soft Matt. 2014, 10, 600-608.
Carrasco-Sánchez, V., Vergara-Jaque, A., Zuñiga,M., Comer, J., John, A., Nachtigall,F.M., Valdes ,O., Duran-Lara,E. F., Sandoval ,C., Santos, L.S. "In situ and in silico evaluation of amine- and folate-terminated dendrimers as nanocarriers of anesthetics" Eur. J. Med. Chem. 2014, 73, 250-257.
Jackisch-Matsuura, A. B., Santos, L. S., Eberlin, M. N., de Faria, A. F., Matsuura, T., Durrant, L. R "Production and Characterization of Surface-active Compounds from Gordonia amicalis" Braz. Arch. Biol. Technol. 2014, 58, 138-144.
--- 2013 ---
Duran-Lara, E., Guzman, L., John, A., Fuentes, E., Alarcon, M., Palomo, I., Santos, L. S. "PAMAM dendrimer derivarives as a potential drug for antithrombotic therapy" Eur. J. Med. Chem. 2013, 69, 601-608.
Pyarasani, R. D., John, A., Santos, L. S. "Recent Developments of Chiral Induction in the Syntheses of Biologically Important Alkaloids" Curr. Top. Med. Chem. 2013, 13, 2184-2199.
Fuentes,E., Forero-Doria, O., Carrasco, G., Maricán, A., Santos, L. S., Alarcón, M., Palomo, I. "Effect of Tomato Industrial Processing on Phenolic Profile and Antiplatelet Activity" Molecules 2013, 18, 11526-11536. doi:10.3390/molecules180911526
Marican, A., Simirgiotis, M. J., Santos, L. S. "Asymmetric total synthesis of Tofacitinib" Tetrahedron Lett. 2013, 54, 5096-5098.
Mirabal-Gallardo, Y., Soriano, M. D. P. C., Santos, L. S. "Stereoselective bioreduction of β-Carboline imines through cell-free extract from earthworms (Eisenia foetida)" Tetrahedron Asymm. 2013, 24, 440-443.
--- 2012 ---
John, A., Nachtigall, F. M., Santos, L. S. "Dendritic Catalysis in Asymmetric Synthesis" Curr. Org. Chem. 2012, 17, 1776-1787. (Review)
Avila-Salas, F., Sandoval, C., Caballero, J., Guinez Molinos, S., Santos, L. S., Cachau, R., Gonzalez-Nilo, F. "Study of Interaction Energies Between PAMAM Dendrimer and non-Steroidal anti-Inflammatory Drug Using a Distributed Computational Strategy and Experimental Analysis by ESI-MS" J. Phys. Chem. B 2012, 116, 2031-2039.
Mirabal-Gallardo, M., Pierola, J., Shankaraiah, N., Santos, L. S. "Enantioselective Total Synthesis of (S)-(+)-Lennoxamine Through Asymmetric Hydrogenation Mediated by L-Proline Ruthenium Catalyst" Tetrahedron Lett. 2012, 53, 3672-3675.
Soriano, M. D. P. C., Simirgiotis, M. J., Mirabal-Gallardo,Y., Santos, L. S. "Supramolecular host-guest asymmetric induction in organic synthesis" Curr. Org. Synth. 2012, 9, 279-309. (Review).
Laurie, V. F., Zuniga, M. C., Carrasco-Sanchez, V., Santos, L. S., Canete, A., Olea-Azar, C., Ugliano, M., Agosin, E. "Reactivity of 3-sulfanyl-1-hexanol and catechol-containing phenolics in vitro" Food Chemistry 2012, 131, 1510-1516.
Mirabal-Gallardo, Y., Soriano, M. D. P. C., Caballero, J., Alzate-Morales, J., Simirgiotis, M. J., Santos, L. S. "Short Synthesis of Indolo[2,3-a]quinolizidine Ring through the Addition of 1-Siloxyfurans to Imines" Synthesis 2012, 1, 144-150.
Villagra, E., Santos, L. S., Vaz, B. G., Eberlin, M. N., Laurie, V. F. "Varietal discrimination of Chilean wines by direct injection mass spectrometry analysis combined with multivariate statistics" Food Chem. 2012, 131, 692-697.
Catharino, R. R., Santos, L. S. "On-line monitoring of Stevioside sweetener hydrolysis to steviol in acidic aqueous solutions" Food Chem. 2012, 133, 1632-1635.
Espinoza-Moraga, M., Caballero, J., Gaube, F., Winkler, T., Santos, L. S. "1-Benzyl-1,2,3,4-Tetrahydro-beta-Carboline as Channel Blocker of N-Methyl-D-Aspartate Receptors" Chem. Biol. Drug Design 2012, 79, 594-599.
--- 2011 ---
Shankaraiah, N., Markandeya, N., Srinivasulu, V., Sreekanth, K., Reddy, C. R, Santos, L. S., Kamal, A. "A One-Pot Azido Reductive Tandem Mono-N-Alkylation Employing Dialkylboron Triflates: Onlline ESI-MS Mechanistic Investigation" J. Org. Chem. 2011, 76, 7017–7026.
Aguirre, M. J., Isaacs, M., Matsuhiro, B., Mendoza, L., Santos, L. S., Torres, S. "Anthocyanin composition in aged Chilean Cabernet Sauvignon red wines" Food Chem. 2011, 129, 514-519.
Geraldo, D. A., Duran-Lara, E. F., Aguayo, D., Cachau, R., Tapia, J., Esparza, R., Yacaman, M- J., Gonzalez-Nilo, F. D., Santos, L. S. "Supramolecular Complexes of Quantum Dots and PAMAM-Folate derivative for Molecular Imaging of Cancer Cells" Anal. Bioanal. Chem.2011, 400, 483-492.
Santos, L. S., Mirabal-Gallardo, Y., Shankaraiah, N., Simirgiotis, M. J. "Short Total Synthesis of (-)-Lupinine and (-)-Epiquinamide by Double Mitsunobu reactions" Synthesis 2011, 51-56.
Kamal, A.; Reddy, M. K.; Reddy, T. S.; Santos, L. S.; Shankaraiah, N. "Total syntheses of rutaecarpine and their analogues employing azido reductive tandem-cyclization assisted by microwave irradiation" Synlett 2011, 61-64.
Silva, B. V., Violante, F. A., Pinto, A. C., Santos, L. S. "The mechanism of Sandmeyer's cyclization reaction by electrospray ionization mass spectrometry" Rapid Commun. Mass Spectrom. 2011, 25, 423-428.
Gonzalez-Nilo, F., Perez-Acle, T., Guinez-Molinos, S., Geraldo, D., Sandoval, C., Yevenes, A., Santos, L. S., Laurie, F., Mendoza, H., Cachau, R. "Nanoinformatics: an emerging area of information technology at the intersection of bioinformatics, computational chemistry and nanobiotechnology" Biol. Res. 2011, 44, 41-49.
Santos, L. S. "What do we know about reaction mechanism? The Electrospray Ionization Mass Spectrometry Approach" J. Braz. Chem. Soc. 2011, 22, 1827-1840. (Accounts)
Catharino, R. R., Haddad, R., Godoy, H. T., Eberlin, M. N., Santos, L. S. "Fast Analysis of Taurine in Energetic Drinks by Direct Infusion Electrospray Ionization Tandem Mass Spectrometry" J. Braz. Chem. Soc. 2011, 22, 801-806.
Quispe, C., Nachtigall, F. M., Fonseca, M. F. R., Alberici, R. M., Astudillo, L., Villaseñor, J., Eberlin, M. N., Santos, L. S. "On-line Monitoring of ß-Blockers Ozone Degradation via Electrospray Ionization Mass Spectrometry" J. Braz. Chem. Soc. 2011, 22, 917-926.
--- 2010 ---
Santos, L.; Espinoza Moraga, M.; Shankaraiah, N. "Enantioselective synthesis of asymmetric beta-carboline intermediates" PCT Int. Appl. 2010, 38pp. CODEN: PIXXD2 WO 2010060228 A1 20100603.
Soriano, M. D. P. C., Shankaraiah, N., Santos, L. S. "Short synthesis of Noscapine, Bicuculline, Egenine, Capnoidine and Corytensine alkaloids through the addition of 1-siloxy-isobenzofurans to imines" Tetrahedron Lett. 2010, 51, 1770–1773.
Espinoza-Moraga, M., Petta, T., Vasquez-Vasquez, M., Laurie, F., Moraes, L. A. B., Santos, L. S. "Bioreduction of ß-carboline Imines to Amines Employing Saccharomyces bayanus" Tetrahedron Asymm. 2010, 21, 1988-1992.
Shankaraiah, N., Markandeya, N., Reddy, Ch. S., Santos, L. S., Kamal, A. "Efficient enantioselective syntheses of piperidinobenzodiazepines through ‘cation pool’ host/guest supramolecular co-catalyzed asymmetric addition to N-acyliminium and their DNA binding studies" Tetrahedron Asymm. 2010, 21, 2625-2630.
--- 2009 ---
Santos, L. S., Espinoza-Moraga, Nagula, S."Sintesis enantioselectiva de intermediario beta-carbolina asimetricos para obtener pirrolo-quinolonas con la capacidad de inhibir la Fosfodiesterasa tipo 5" DPI2009, 03573.
Kamal, A., Markandeya, N., Shankaraiah, N., Reddy, C. R., Prabhakar, S., Reddy, C. S., Eberlin, M. N., Santos, L. S. "Chemoselective Aromatic Azido Reduction with Concomitant Aliphatic Azide Employing Al/Gd Triflates-NaI and ESI-MS Mechanistic Studies" Chem. Eur. J. 2009, 15, 7215-7224.
da Silva,W. A., Rodrigues Jr., M. T., Shankaraiah, N., Ferreira, R. B., Andrade, C. K. Z., Pilli, R. A., Santos, L. S. "A novel Supramolecular Palladium Catalyst for the Asymmetric Reduction of Imines in Water" Org. Lett. 2009, 11, 3238-3241.
Carrasco-Sanchez, V., Simirgiotis, M. J., Santos, L. S. "The Morita-Baylis-Hillman reaction: Asymmetric insights and mechanism reactions by Electrospray Ionization Mass Spectrometry" Molecules 2009, 14, 3989-4021.
Shankaraiah, N., Santos, L. S. "Enantioselective total synthesis of pyrroloquinolone as a potent PDE5 inhibitor" Tetrahedron Lett. 2009, 50, 520-523.
Espinoza-Moraga, M., Cornejo-Morales, R., Santos, L. S. "Synthesis and absolute configuration of (S)-(+)-chichimol ketone: the defensive
secretion of walking stick Agathemera elegans" Tetrahedron: Asymmetry 2009, 20, 1062-1064.
Duran-Lara, E. F., Shankaraiah, N., Geraldo, D., Santos, L. S. "Studies Towards the Construction of Quaternary Indolizidines by [2,3]-Sigmatropic Rearrangement Cocatalyzed by Ionic Liquid" J. Braz. Chem. Soc. 2009, 20, 813-819.
Shankaraiah, N., Santos, L. S. "Corrigendum to Enantioselective total synthesis of pyrroloquinolone as a potent PDE5 inhibitor" Tetrahedron Lett. 2009, 50, 2700.
Shankaraiah, N., Markandeya, N., Espinoza-Moraga, M., Kamal, A., Santos, L. S. "One-pot Microwave-Assisted Ni2B Selective Reduction of Azido and Nitro Derivatives Tandem Cyclization in Condensed and Solid-Phase" Synthesis 2009, 2163-2170.
Santos, L. S., Theoduloz, C., Pilli, R. A., Rodriguez, J. "Antiproliferative activity of arborescidine alkaloids and derivatives" Eur. J. Med. Chem.2009, 44, 3810-3815.
Espinoza-Moraga, M., Caceres, A. G., Santos, L. S. "Palladium Asymmetric Reduction of b-Carboline Imines mediated by Chiral Auxiliaries Assisted by Microwave Irradiation" Tetrahedron Lett. 2009, 50, 7059–7061 .
--- 2008 ---
Santos, L. S. "Online Mechanistic Investigations of Catalyzed Reactions by Electrospray Ionization Mass Spectrometry: A Tool to Intercept Transient Species in Solution" Eur. J. Org. Chem. 2008, 235-253. (Review)
Santos, L. S., Metzger, J. O. "On-Line Monitoring of Brookhart Polymerization by Electrospray Ionization Mass Spectrometry" Rap. Comm. Mass Spectrom. 2008, 22, 898-904.
Shankaraiah, N., Silva, W. A., Andrade, C. K. Z., Santos, L. S. "Enantioselective Total Synthesis of (S)-(-)-Quinolactacin B" Tetrahedron Lett. 2008, 49,4289–4291.
Shankaraiah, N., Pilli, R. A., Santos, L. S. "Enantioselective Total Syntheses of Ropivacaine and its Analogues" Tetrahedron Lett. 2008, 49, 5098-5100.
Espinoza, M., Santos, L. S., Theoduloz, C., Schmeda-Hirschmann, G., Rodríguez, J. A. "New Gastroprotective Ferruginol Derivatives with Selective Cytotoxicity against Gastric Cancer Cells" Planta Medica 2008, 74, 802-808.
--- 2007 ---
Santos, L. S., Rosso, G. B., Pilli, R. A., Eberlin, M. N. "The Mechanism of the Stille Reaction Investigated by Electrospray Ionization Mass Spectrometry" J. Org. Chem. 2007, 72, 5809-5812.
Abella, C. A. M., Benassi, M., Santos, L. S., Eberlin, M. N., Coelho, F. "The Mechanism of Troger’s Base Formation Probed by Electrospray Ionization Mass Spectrometry" J. Org. Chem. 2007, 72, 4048-4054.
Lopes, A. S., Garcia, J. S., Catharino, R. R., Santos, L. S., Eberlin, M. N., Arruda, M. A. Z. "Cloud point extraction applied to casein proteins of cow milk and their identification by mass spectrometry" Anal. Chimica Acta 2007, 590, 166-172.
Santos, L. S., Cunha, , R. L. O. R., Comasseto, J. V., Eberlin, M. N. "Electrospray ionization mass spectrometric characterization of key Te(IV) cationic intermediates for the addition of TeCl4 to alkynes" Rapid Commun. Mass Spectrom. 2007, 21, 1479-1484.
Milagre, C. D. F., Milagre, H. M. S., Santos, L. S., Lopes, M. A. L., Moran, P. J. S., Eberlin, M. N., Rodrigues, J. A. R. "Probing the mechanism of direct Mannich-type alfa-methylenation of ketoesters via electrospray ionization mass spectrometry" J. Mass Spectrom. 2007, 42, 1287-1293.
Pertino, M., Schmeda-Hirschmann, G., Santos, L. S., Rodriguez, J. A., Theoduloz, C. "Biotransformation of Jatrophone by Aspergillus niger ATCC 16404" Zeitschrift Naturf. 2007, 2, 275-279.
Oliveira, M. T., Prado, M. A. F., Alves, R. B., Cesar, A., Alves, R. J., Queiroga,C. G., Santos, L. S., Eberlin, M. N. "tri-n-Butyltin Hydride-Mediated Radical Reaction of a 2-Iodobenzamide: Formation of an Unexpected Carbon-Tin Bond" J. Braz. Chem. Soc. 2007, 18, 364-369.
--- 2006 ---
DaSilveira Neto, B. A.,Santos, L. S., Nachtigall, F. M., Eberlin,M. N., Dupont, J. "On the Species Involved in the Vaporization of Imidazolium Ionic Liquids in a Steam-Distillation-Like Process" Angew. Chem. Int. Ed. 2006, 45, 7251-7254. (2005 Impact Factor: 9.596)
DaSilveira Neto, B. A.,Santos, L. S., Nachtigall, F. M., Eberlin,M. N., Dupont, J. "On the Species Involved in the Vaporization of Imidazolium Ionic Liquids in a Steam-Distillation-Like Process" Angew. Chem.2006, 118, 7409-7412. (2005 Impact Factor: 9.596)
Santos, L. S., Metzger, J. O. “Study of Homogeneously Catalyzed Ziegler-Natta Polymerization of Ethene Using Electrospray Ionization Mass Spectrometry” Angew. Chem. Int. Ed. 2006, 45, 977-981. (2005 Impact Factor: 9.596)
Santos, L. S., Metzger, J. O. “Untersuchung der homogen katalysierten Ziegler-Natta-Polymerisation von Ethen mittels ESI-MS” Angew. Chem. 2006, 118, 991 –995.(2005 Impact Factor: 9.596)
Noronha, L.A, Judson, T. J. L., Dias, J. F., Santos, L. S., Eberlin, M. N., Mota, C. J. A. “Intrinsic Acidity of Dimethylhalonium Ions: Evidence for Hyperconjugation in Dimethylhalonium Ylides in the Gas Phase” J. Org. Chem. 2006, 71, 2625-2629. (2005 Impact Factor: 3.675)
Ferreira, C. S., Santos, L. S., Eberlin, M. N., Frézard, F., Demicheli, C. “Synthesis and Characterization of Sb(V)-Adenosine and Sb(V)-Guanosine Complexes” Inorg. Chimica Acta 2006, 359, 159–167. (2005 Impact Factor: 1.606)
Meurer, E. C., Rocha, L. L., Pilli, R. A., Eberlin, M. N., Santos, L. S. "Transient intermediates of the Tebbe reagent intercepted and characterized by atmospheric pressure chemical ionization mass spectrometry" Rap. Commun. Mass Spectrom. 2006, 20, 2626-2629. (2005 Impact Factor: 3.087)
Santos, L. S., Dalmazio, I., Eberlin, M. N., Claeys, M., Augusti, R. “Mimicking the atmospheric OH-radical-mediated photooxidation of isoprene: formation of cloud-condensation nuclei polyols monitored by electrospray ionization mass spectrometry” Rap. Commun. Mass Spectrom. 2006, 20, 2104-2108. (2005 Impact Factor: 3.087)
Moura, F. C. C., Araujo, M. H., Dalmazio, I., Alves, T. M. A., Santos, L. S., Eberlin, M. N., Augusti, R., Lago, R. M. “Investigation of reaction mechanisms by electrospray ionization mass spectrometry: characterization of intermediates in the degradation of phenol by a novel iron /magnetite/hydrogen peroxide heterogeneous oxidation system” Rap. Commun. Mass Spectrom. 2006, 20, 1859–1863. (2005 Impact Factor: 3.087)
Cerchiaro, G., Da Costa Ferreira, A. M., Teixeira, A. B., Magalhaes H. M., Cunha, A. C., Ferreira, V. F., Santos, L. S., Eberlin, M. N., Skakle, J. M. S., Wardell, S. M.S.V., Wardell, J. L. “Synthesis and crystal structure of 2,4-dihydro-4-[(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)imino]-5-methyl-2-phenyl-3H-pyrazol-3-one and its copper(II) complex” Polyhedron 2006, 25, 2055-2064. (2005 Impact Factor: 1.957)
Santos, L. S., DaSilveira Neto, B. A., Consorti, C. S., Pavam, C. H., Almeida, W. P., Coelho, F., Dupont, J., Eberlin, M. N. J. Phys. Org. Chem. 2006,19, 731-736. (2005 Impact Factor: 1.528)
Nasser,A. L. M., Mazzolin, L. P.,Hiruma-Lima, C. A., Santos, L. S., Eberlin, M. N., Monteiro de Souza Brito, A. R., Vilegas, W. Chromatographia 2006, 64, 695-699. (2005 Impact Factor: 0.959)
Santos, L. S., Catharino, R. R., Aguiar,C. L., Tsai, S. M., Eberlin, M. N. "Chemotaxonomic markers of organic, natural, and genetically modified
soybeans detected by direct infusion electrospray ionization mass spectrometry" J. Radioanal. Nucl. Chem. 2006, 269, 505–509.(2005 Impact Factor: 0.460)
Silva, L. F., Quintiliano, S. A. P., Ferraz, H. M. C., Santos, L. S., Eberlin, M. N. "Oxidation of Tertiary Homoallylic Alcohols by Thallium Trinitrate: Fragmentation vs. Ring Contraction" J. Braz. Chem. Soc. 2006, 17, 981-988. (2005 Impact Factor: 1.097)
Pilli, R. A., Silva Santos, L "Production of vacain derivative type anaesthetics comprises formation of (S)-L-pipecolic acid intermediate for levobupivacain and (S)-L-mepivacain" BR200302250-A 2005-323110/34.
---2005---
Ferraz, H. M. C., Gonçalo, E. R. S., Santos, L. S., Marcos N. Eberlin “Mechanistic Study in the Synthesis of GABA restrict Conformational Analogs Applying ESI(+)-MS/MS” J. Org. Chem. 2005, 70, 110-114. (2005 Impact Factor: 3.675)
Catharino, R. R., Marques, L. A., Santos, L. S., Baptista, A. S., Glória, E. M., Calori-Domingues, M. A., Facco, E. M. P., Eberlin, M. N. “Fast High-Throughput Screening of Aflatoxins by MALDI-TOF Mass Spectrometry Analysis” Anal. Chem. 2005, 77, 8155-8157. (2005 Impact Factor: 5.635)
Santos, L. S., Knaack, L., Metzger, J. O. “Investigation of chemical reactions in solution using API-MS” Int. J. Mass Spectrom. 2005, 246, 84-104. (2005 Impact Factor: 2.098)
Dalmázio, I., Santos, L. S., Lopes, R. P., Eberlin, M. N., Augusti, R. “Advanced Oxidation of Caffeine in Water: On-Line and Real-Time Monitoring by Electrospray Ionization Mass Spectrometry” Environ. Sci. Techol. 2005, 39, 5982-5988. (2005 Impact Factor: 4.054)
Milagre, C. D. F., Milagre, H. M. S., Rodrigues, J. A. R., Rocha, L. L., Santos, L. S., Eberlin, M. N. “On-line Monitoring of Bioreductions via Membrane Introduction Mass Spectrometry” Biotechnology & Bioengineering 2005, 90, 888-892. (2005 Impact Factor: 2.483)
Santos, L. S., Padilha, M. C., de Aquino Neto, F. R., Pereira,A. S., Menegatti, R., Fraga, C. A. M., Barreiro,E. J., Eberlin, M. N. “Eletrospray Ionization Mass and Tandem Mass Spectra of a Series of N-Pyrazolylmethyl and N-Triazolylmethyl N-Phenylpiperazines: New Dopaminergic Ligands with Potential Antipsychotic Properties” J. Mass Spectrom. 2005, 40, 815-820. (2005 Impact Factor: 3.574)
Ribeiro, A. B., Bolzani, V. da S., Yoshidab, M., Santos, L. S., Eberlin, M. N., Silva, D. H. S. “New Lignan and Antioxidant Phenols from Nectandra grandiflora” J. Braz. Chem. Soc. 2005, 16, 526-530. (2005 Impact Factor: 1.097)
Andresa, J. S., Reis,R. M., Gonzalez,E. P., Santos, L. S., Eberlin, M. N., Nascente, P. A. P., Tanimoto, S. T., Machado, S. A. S., Rodrigues-Filho, U. P. “Adsorption of Silanes Bearing Nitrogenated Lewis Bases on SiO2/Si (100) Model Surfaces” J. Colloidal and Interface Science 2005, 286, 303-309. (2005 Impact Factor: 2.023)
Santos, L. S., Catharino, R. R., Eberlin, M. N. “The Proton-Bound Dimer of Acetone” J. Mass Spectrom. 2005, 40, 127-128. (2005 Impact Factor: 3.574)
Santos, L. S., Pavam, C. H., Almeida, W. P., Coelho, F., Eberlin, M. N.“Probing the Mechanism of the Baylis-Hillman Reaction by Electrospray Ionization Mass and Tandem Mass Spectrometry” Angew. Chem. Int. Ed. 2004, 43, 4330-4333. (2005 Impact Factor: 9.596)
Santos, L. S., Pavam, C. H., Almeida, W. P., Coelho, F., Eberlin, M. N. “die Einheit der Baylis-Hillman Reaktion Durch Electrospray Ionization Masse und Tandemmassenspektrometrie Prüfend” Angew. Chem. 2004, 116, 4430-4433. (2005 Impact Factor: 9.596)
Gozzo, F. C., Santos, L. S., Augusti, R., Consorti, C. S., Dupont, J., Eberlin, M. N. “Gaseous Supramolecules of Imidazolium Ionic Liquids: “Magic” Numbers for Clustering and Intrinsic Strengths of Hydrogen Bonds” Chemistry- A European Journal 2004, 10, 6187-6193. (2005 Impact Factor: 4.907)
Domingos, J. B., Longhinotti, E., Brandão, T. A. S., Bunton, C. A., Santos, L. S., Eberlin, M. N., Nome, Faruk. “Reaction of Bis(2,4-dinitrophenyl) Phosphate with Hydrazine and Hydrogen Peroxide. Comparing O- and N- Phosphorylation” J. Org. Chem. 2004, 69, 7898-7905. (2005 Impact Factor: 3.675)
Domingos, J. B., Longhinotti, E., Brandão, T. A. S., Bunton, C. A., Santos, L. S., Eberlin, M. N., Nome, F. “Mechanisms of Nucleophilic Substitution Reactions of Methylated Hydroxylamines with Bis(2,4-dinitrophenyl)phosphate. Mass Spectrometric Identification of Key Intermediates” J. Org. Chem. 2004, 69, 6024-6033. (2005 Impact Factor: 3.675)
Raminelli, C., Prechtl, M. H. G., Santos, L. S., Eberlin, M. N., Comasseto, J. V. “Improved Procedure for the Coupling of Vinylic Tellurides with Alkynes Catalyzed by Palladium Dichloride” Organometallics 2004, 23, 3990-3996. (2005 Impact Factor: 3.473)
Sorrilha, A. E. P. M., Santos, L. S., Gozzo, F. C., Sparrapan, R., Augusti, R., Eberlin, M. N. “Intrinsic Reactivity of Gaseous Halocarbocations Toward Prototype Aromatic Compounds” J. Phys. Chem. A 2004, 108, 7009-7020. (2005 Impact Factor: 2.898)
de Oliveira, R. B., Filho, J. D. S., Prado, M. A. F., Eberlin, M. N., Meurer, E. C., Santos, L. S., Alves, R. J. “Synthesis of Unexpected Twelve-Membered Macrocycles by Free-Radical Carbocyclisation on Carbohydrate Templates” Tetrahedron 2004, 60, 9901-9908. (2005 Impact Factor: 2.618)
Santos, L. S., Addad, R., Höehr, N. F., Pilli, R. A., Eberlin, M. N. “Rapid Screening of Synthetic Alkaloids Through a Two-Dimension Analyses by TLC-MALDI-TOF” Anal. Chem. 2004, 76, 2144-2147. (2005 Impact Factor: 5.635)
Santos, L. S., Pilli, R. A., Rawal, V. H. “Enantioselective Total Synthesis of Arborescidines A, B and C Through the Noyori Asymmetric Hydrogenation” J. Org. Chem. 2004, 69, 1283-1289. (2005 Impact Factor: 3.675)
Santos, L. S., Meurer, E. C., Pilli, R. A., Eberlin, M. N. “Probing the Mechanism of the Petasis Olefination Reaction by Atmospheric Pressure Chemical Ionization Mass Spectrometry” Org. Lett. 2003, 5, 1391-1394. (2005 Impact Factor: 4.368)
Santos, L. S., Pilli, R. A. “Studies Towards the Construction of Alkylidene Quinolizidines. The Total Synthesis of Homopumiliotoxin 223G” J. Braz. Chem. Soc. 2003, 14, 982-993. (2005 Impact Factor: 1.097)
Santos, L. S., Fernandes, S. A., Marsaioli, A. J., Pilli, R. A. “A Novel Asymmetric Reduction of Dihydro-b-Carboline Derivatives Using Calix[6]Arene/Chiral Amine as a Host Complex” Tetrahedron: Asymmetry 2003, 17, 2515-2519. (2005 Impact Factor: 2.429)
Santos, L. S., Pilli, R. A. “The Intramolecular Heck Reaction and the Synthesis of Indolizidinone, Quinolizidinone and Benzoazepinone Derivatives” Synthesis 2002, 87-93. (2005 Impact Factor: 2.401)
Santos, L. S., de Oliveira, M. C. F., Pilli, R. A. “Diastereoselection of the Addition of Silyloxyfurans to Five-, Six- and Seven-Membered N-Acyliminium Ions” Tetrahedron Lett. 2001, 42, 6995-6997. (2005 Impact Factor: 2.477)
Santos, L. S., Pilli, R. A. “Total Synthesis of (±)-Homopumiliotoxin 223G” Tetrahedron Lett. 2001, 42, 6999-7001. (2005 Impact Factor: 2.477)
Pilli, R. A., Santos, L. S. “Processo de Obtenção dos Anestésicos Levobupivacaína e (S)-L-Mepivacaína” INPI 2003, PI0302.250-1.
Sitio Web
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Dr. Guillermo Schmeda Hirschmann
Formación Profesional
BIOQUÍMICO, Universidad Nacional de Asunción, Paraguay (1978) (convalidado por la Universidad de Chile, 1990)
DR. RER. NAT., 1984 INSTITUT FÜR ORGANISCHE CHEMIE, TECHNISCHE UNIVERSITÄT BERLIN. Director de Tesis: Prof. Dr. FERDINAND BOHLMANN.
Título de la Tesis: Isolierung und Strukturaufklärung von Pflanzeninhaltsstoffen aus Compositae
Publicaciones
• De la Torre, A.F., Ali, A., Westermann, B., Schmeda-Hirschmann, G., Pertino, M.W. (2019). An efficient cyclization of Lapachol to new benzo[h]chromene hybrid compounds: Tandem vs one-pot esterification-click (CuAAC) study. New Journal of Chemistry, Manuscript ID: NJ-ART-07-2018-003699.
• Schmeda-Hirschmann, G., Burgos-Edwards, A., Theoduloz, C., Jiménez-Aspee, F., Vargas-Arana, G. (2019). Male sexual enhancers from the Peruvian Amazon. Journal of Ethnopharmacology 229, 167-179 DOI 10.1016/j.jep.2018.10.007.
• Schmeda-Hirschmann, G., Theoduloz, C. (2019). Fabiana imbricata Ruiz et Pav. (Solanaceae), a review of an important Patagonian medicinal plant. Journal of Ethnopharmacology 228, 26-39.
• Theoduloz, C., Alzate-Morales, J., Jiménez-Aspee, F., Isla, M.I., Alberto, M.R., Pertino, M.W., Schmeda-Hirschmann, G. (2018). Inhibition of key enzymes in the inflammatory pathway by hybrid molecules of terpenes and synthetic drugs: in vitro and in silico studies. Chem. Biol. Drug. Des. 2018;00:1-10 DOI: 10.1111/cbdd.13415.
• Moreno, M.A., Gómez-Mascaraque, L.G., Arias, M., Zampini, I.C., Sayago, J.E., Pino R., L.L., Schmeda-Hirschmann, G., López-Rubio, A., Isla, M.I. Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations (2018). Carbohydrate Polymers 201, 425-437.
• Jimenez Aspee, F., Theoduloz, C., Gómez-Alonso, S., Hermosín Gutierrez, I., Reyes, M., Schmeda-Hirschmann, G. (2018). Polyphenolic profile and antioxidant activity of the Chilean "chagual" (Puya chilensis Mol.), a salad from central Chile. Food Research International 114, 90-96.
• Tallini, L.R., Bastida, J., Cortes, N., Osorio, E.H., Theoduloz, C., Schmeda-Hirschman, G. (2018). Cholinesterase inhibition activity, alkaloid profiling and molecular docking of Chilean Rhodophiala (Amaryllidaceae). Molecules 2018, 23, 1532; doi:10.3390/molecules23071532 (27 pp).
• Jimenez-Aspee, F., Theoduloz, C., Burgos-Edwards; A., Schmeda-Hirschmann, G. (2018). Effect of polyphenols from wild Chilean currants (Ribes spp.) on the activity of intracellular antioxidant enzymes in human gastric AGS cells. Food Bioscience 24, 80-88.
• Pertino, M.W., Petrera, E., Alché, L.E., Schmeda-Hirschmann, G. (2018). Synthesis, antiviral and cytotoxic activity of novel terpenyl hybrid molecules prepared by click chemistry. Molecules 2018, 23, 1343; doi:10.3390/molecules23061343, 12 pp.
• Zolezzi, J.M., Lindsay, C.B., Serrano, F.G., Ureta, R.C., Theoduloz, C., Schmeda-Hirschmann, G., Inestrosa, N.C. (2018). Neuroprotective effects of ferruginol, jatrophone, and junicedric acid against amyloid-β injury in hippocampal neurons. Journal of Alzheimer´s Disease 63, 705-723 DOI: 10.3233/JAD-170701.
• Burgos-Edwards, A., Jiménez-Aspee, F., Theoduloz, C., Schmeda-Hirschmann, G. (2018). Colonic fermentation of polyphenols from Chilean currants (Ribes spp.) and its effect on antioxidant activity and metabolic syndrome-associated enzymes. Food Chemistry 258, 144-155. DOI information: 10.1016/j.foodchem.2018.03.053.
• Moreno, M.A., Córdoba, S., Zampini, I.C., Mercado, M.I., Ponessa, G., Sayago, J.E., Pino R., L.L., Schmeda-Hirschmann, G., Isla, M.I. (2018). Argentinean Larrea dry extracts with potential use in vaginal candidiasis. Natural Products Communications 13 (2), 171-174.
• Moreno, M.A., Córdoba, S., Zampini, I.C., Alberto, M.R., Mercado, M.I., Nader-Macias, M.E.F., Sayago, J., Burgos-Edwards, A., Schmeda-Hirschmann, G., Isla, M.I. (2018). Tetraglochin andina Ciald.: a medicinal plant from the Argentinean highlands with potential use in vaginal candidiasis. Journal of Ethnopharmacology 216 283–294.
• Ávila, F., Schmeda-Hirschmann, G., Silva, E. (2018). The major chromophore arising from glucose degradation and oxidative stress occurrence during lens proteins glycation induced by glucose. Molecules 23, 6; pp 1-13 doi:10.3390/molecules23010006.
• Thomas-Valdés, S., Theoduloz, C., Jiménez-Aspee, F., Burgos-Edwards, A., Schmeda-Hirschmann, G. (2018). Changes in polyphenol composition and bioactivity of the native Chilean white strawberry (Fragaria chiloensis spp. chiloensis f. chiloensis) after in vitro gastrointestinal digestion. Food Research International 105, 10-18.
• Jiménez-Aspee, F., Theoduloz, C., Soriano, M. del P. C., Ugalde-Arbizu, M., Alberto, M.R., Zampini, I.C., Isla, M.I., Simirgiotis, M.J., Schmeda-Hirschmann, G. (2017). The native fruit Geoffroea decorticans from the arid northern Chile: phenolic composition, antioxidant activities and in vitro inhibition of pro-inflammatory and metabolic syndrome associated enzymes. Molecules 22, 1565, 18 pp. PDF Version: http://www.mdpi.com/1420-3049/22/9/1565/pdf
Molecules 2017, 22, 1565; doi:10.3390/molecules22091565.
• Strada, C.L., da Costa Lima, K., da Silva, V.C., Ribeiro, R.V., Dores, E.F.G de C., Dall'Oglio, E.L., Schmeda-Hirschmann, G., Carollo, C.A., Martins, D.T. de O., de Sousa Junior, P.T. (2017). Isovitexin as marker and bioactive compound in the antinociceptive activity of the Brazilian crude drug extracts of Echinodorus scaber and E. grandiflorus. Revista Brasileira de Farmacognosia https://doi.org/10.1016/j.bjp.2017.05.011 ISSN: 0102-695X Elsevier Scielo.
• Orqueda, M.E., Zampini, I.C., Torres, S., Alberto, M.R., Pino Ramos, L.L., Schmeda-Hirschmann, G., Isla, M.I. (2017). Chemical and functional characterization of skin, pulp and seed powder from the Argentine native fruit Mistol (Ziziphus mistol). Effects of phenolic fractions on key enzymes involved in metabolic syndrome and oxidative stress. Journal of Functional Foods 37, 531-540.
• Burgos-Edwards, A., Jiménez-Aspee, F., Thomas-Valdés, S., Schmeda-Hirschmann, G., Theoduloz, C. (2017). Qualitative and quantitative changes in polyphenol composition and bioactivity of Ribes magellanicum and R. punctatum after in vitro gastrointestinal digestion. Food Chemistry 237, 1073-1082.
• Torres Carro, R., Isla, M.I., Thomas-Valdes, S., Jiménez-Aspee, F., Schmeda-Hirschmann, G., Alberto, M.R. (2017). Inhibition of pro-inflammatory enzymes by medicinal plants from the Argentinean highlands (Puna). Journal of Ethnopharmacology 205, 57-68.
• Pertino, M.W., Vega, C., Rolón, M., Coronel, C., Rojas de Arias, A., Schmeda-Hirschmann, G. (2017). Antiprotozoal activity of triazole derivatives of dehydroabietic acid and oleanolic acid. Molecules 22, 369; doi:10.3390/molecules22030369.
• Ávila, F., Theoduloz, C., López-Alarcón, C., Dorta, E., Schmeda-Hirschmann, G. (2017). Cytoprotective effect mediated by polyphenols from Chilean native berries against free radical-induced damage on AGS cells. Oxidative Medicine and Cellular Longevity (Article ID 9808520, 13 pages)
• Schmeda-Hirschmann, G., Burgos-Edwards, A., Rojas de Arias, A., Vega G., C., Alfonso, J., Rolon, M., Brusquetti, F., Netto, F., Urra, F.A., Cárdenas, C. (2017). The Paraguayan Rhinella toad venom: Implications in the traditional medicine and proliferation of breast cancer cells. Journal of Ethnopharmacology 199, 106-118.
• Jiménez-Aspee, F., Theoduloz, C., Vieira, M.N., Rodriguez-Werner, M.A., Schmalfuss, E., Winterhalter, P., Schmeda-Hirschmann, G. (2016). Phenolics from the Patagonian currants Ribes spp.: isolation, characterization and cytoprotective effect in AGS cells. Journal of Functional Foods 26, 11-26.
• Cattaneo, F., Costamagna M.S., Zampini I.C., Sayago, J., Alberto M.R., Chamorro V., Pazos A., Thomas-Valdés, S., Schmeda-Hirschmann, G., Isla, M.I. (2016). Flour from Prosopis alba cotyledons: a natural source of nutrient and bioactive phytochemicals. Food Chemistry 208, 89-96.
• Nina, V., Quispe, C., Jimenez-Aspee, F., Theoduloz, C., Leiva, E., Feresin, G.E., Lima, B., Schmeda-Hirschmann, G. (2015). Antibacterial activity, antioxidant effect and chemical composition of propolis from Región del Maule, central Chile. Molecules 20, 18144-18167.
• Pérez, M.J., Cuello, A.S., Zampini, I.C., Ordoñez, R.M., Alberto, M.R., Quispe, C., Schmeda-Hirschmann, G., Isla, M.I. (2014). Polyphenolic compounds and anthocyanin content of Prosopis nigra and Prosopis alba pods flour and their antioxidant and anti-inflammatory capacity. Food Research International 64, 762-771
• Schmeda-Hirschmann, G., Quispe, C., Theoduloz, C., Teixeira de Sousa, P., Parizotto, C. (2014). Antiproliferative activity and new argininyl bufadienolide esters from the “Cururú” toad Rhinella (Bufo) schneideri. Journal of Ethnopharmacology 155, 1076-1085.
• Simirgiotis, M.J., Bórquez, J., Schmeda-Hirschmann, G. (2013). Antioxidant capacity, polyphenolic content and tandem HPLC-DAD-ESI/MS profiling of phenolic compounds from the South American berries Luma apiculata and Luma chequén. Food Chemistry 139, 289-299.
• Simirgiotis, M., Schmeda-Hirschmann, G., Borquez, J., Kennelly. E. (2013). The Passiflora tripartita (banana passion) fruit: a source of bioactive flavonoid C-glycosides isolated by HSCCC and characterized by HPLC–DAD–ESI/MS/MS. Molecules 18, 1672-1692.
• Simirgiotis, M.J., Silva, M., Becerra, J., Schmeda-Hirschmann, G. (2012). Direct characterization of phenolic antioxidants in infusions from four medicinal Mapuche plants by liquid chromatography with diode array detection (HPLC-DAD) and electrospray ionization tandem mass spectrometry (HPLC-ESI-MS). Food Chemistry 131, 318-327.
Link ResearchGate
Post-Doctorado
Editor Asociado
Proyectos Vigentes
Líneas de Investigación
Galería de Fotos
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Dr. Jaime Tapia
Perfil
La base de trabajo es química analítica y ambiental con especial énfasis en la determinación de metales pesados a nivel de trazas por espectroscopia de absorción atómica, utilizando técnicas de llama, horno de grafito y evolución de hidruros. Las determinaciones se realizan en distintos tipos de matrices ambientales: aguas (continentales y marinas), suelos, sedimentos, organismos acuáticos (peces, moluscos, algas) y vegetales.
La línea de investigación está orientada principalmente al uso de bioindicadores para la detección de determinados elementos tóxicos presentes en distintos tipos de ecosistemas.
Formación Profesional
- Bachiller en Química, Universidad de Concepción (1977)
- Licenciado en Química, Universidad de Concepción (1979), Tesis de Grado: Determinación de trazas de cobre, manganeso, vanadio y zinc en esmalte dentario humano por espectroscopía de absorción atómica sin llama y fluoruro con electrodo específico.
- Dr. en Ciencias Ambientales, Universidad de Concepción (1997), Tesis de Grado: Evaluación de la contaminación por cromo en un sistema fluvial de Chile Central. Una propuesta para la disminución en su origen.
Líneas de Investigación
Proyectos Vigentes
Publicaciones
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Dr. Jorge Villaseñor
Perfil
Mi principal trabajo está orientado al estudio y desarrollo de Catalizadores Heterogéneos para aplicaciones medioambientales en el tratamiento de contaminantes industriales en aguas y aire.
También me dedico al estudio de técnicas analíticas para determinación de pesticidas en medios biológicos por técnicas cromatográficas.
Formación Profesional
- Bachiller en Química, Universidad de Concepción (1977)
- Licenciado en Química, Universidad de Concepción (1979), Tesis de Grado: Determinación de trazas de cobre, manganeso, vanadio y zinc en esmalte dentario humano por espectroscopía de absorción atómica sin llama y fluoruro con electrodo específico.
- Dr. en Ciencias Ambientales, Universidad de Concepción (1997), Tesis de Grado: Evaluación de la contaminación por cromo en un sistema fluvial de Chile Central. Una propuesta para la disminución en su origen.
Líneas de Investigación
Proyectos Vigentes
Publicaciones
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Dra. Maria del Pilar Caramantín Soriano
Perfil
Nuestra línea de investigación está asociada al área de productos naturales de plantas nativas en el descubrimiento de fármacos y futuros alimentos con potencial para diversificar las dietas. Estas temáticas involucran elucidación estructural de compuestos bioactivos, actividad biológica, perfil nutricional y compuestos orgánicos volátiles (VOCs). Así mismo, el diseño de “productos verdes” para los sectores alimentario y minero.
Investigadora asociada al Centro de Plantas Nativas (CENATIV) de la Facultad de Ciencias Agrarias de nuestra universidad. Colabora en la misión del CENATIV de contribuir a la innovación, desarrollo tecnológico y capacitación de profesionales que potencien el progreso y el bienestar regional y del país en el ámbito de las especies nativas.
Formación Profesional
Bachiller en Ciencias con mención en Química, Universidad Nacional de Ingeniería, Perú, 1996.
Máster en Química, Universidade Estadual de Campinas, Brasil, 1999.
Doctor en Ciencias con mención en Química, Universidade Estadual de Campinas, Brasil, 2005.
Posición posdoctoral, Geochemistry Laboratory, Universidade Estadual de Campinas, Brasil, 2006.
Posición posdoctoral, Laboratory of Asymmetric Synthesis, Universidad de Talca, Chile, 2009-2011
Líneas de Investigación
Proyectos Vigentes
Publicaciones
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Dr. Fernando Cataldo
Perfil
Profesional con capacidad de trabajo en grupo, con vocación docente y por la investigación en química ambiental y enseñanza de la química. Sus trabajos están orientados a la química teórica, aplicada y experimental, encontrando gran realización en el trabajo con alumnos de pre-grado de las carreras de la área de ingeniería.
Posee presentaciones en conferencias internacionales y publicaciones ISI y SCOPUS. Trabaja en proyectos financiado por FONDEF, EXPLORA, CEAP, Gobierno Regional (FIC-R), además en proyectos con diferentes empresas de la región para implementar soluciones energéticas a partir de desechos, subproductos de desechos, uso de biomasa, plantas de tratamiento y caracterización de RILES y RISES, así como en proyectos de generación de energía eléctrica no convencional. Asesor científico en proyectos CONICYT-EXPLORA. Posee un alto dominio instrumental de laboratorio de química en diversas técnicas analíticas cualitativas y cuantitativas, así como en Química Orgánica y Farmacología de productos naturales
Formación Profesional
Post Doctorado: Universidad de La Laguna, España (1991)
Doctor: Universidad de La Laguna, España (1990)
Licenciado: En Química y Farmacia, Universidad de Chile, Chile (1985)
Líneas de Investigación
Proyectos científicos
Artículos y conferencias
Publicaciones
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Dra. Zoraya López
Perfil
Académico Jornada Completa en calidad de Conferenciante del Cuerpo Académico No Regular, IQRN.
Sólida y contrastada experiencia en investigación y docencia en el área de la Química Inorgánica y Química General. Vasto conocimiento en la síntesis de materiales nanoestructurados inorgánicos, de las técnicas de caracterización y de sus aplicaciones en áreas como catálisis, óptica y sensores. Área de conocimiento: Nanoquímica y Nanotecnología.
Formación Profesional
- Universidad de Chile. Doctora en Química, 2009. Chile. Beca de Doctorado-DAAD (Alemania)
- Instituto Venezolano de Investigaciones Científicas. Magister Scientiarum en Química, 2003. Venezuela. Beca de Magíster-FONACIT (Venezuela).
- Universidad de Carabobo. Licenciada en Química, 2000. Venezuela. Premio mejor estudiante tercer y cuarto año de la carrera.
Líneas de Investigación
Proyectos Vigentes
Publicaciones
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Dr. Mariano Walter Pertino
Perfil
- Semi-sintesis de productos naturales
- Relación estructura-actividad
- Química de productos naturales
Formación Profesional
Doctor en Ciencias (Universidad de Talca)
Licenciado en Química (Universidad Nacional del Sur)
Líneas de Investigación
Publicaciones
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Dr. Adolfo Marican
Perfil
Químico Analítico, con experiencia en determinación de contaminantes inorgánicos y orgánicos a nivel traza en matrices medioambientales y alimentos, optimización y búsqueda de aplicaciones analíticas de polímeros inteligentes, y desarrollo de métodos de extracción de contaminantes orgánicos en matrices medioambientales y alimentos, utilizando diseño experimental y herramientas quimiométricas.
Línea de investigación: Desarrollo de aplicaciones analíticas, de remediación de pesticidas, y de liberación de drogas y medicamentos, utilizando plataformas poliméricas basadas en hidrogeles.
Capacidades I+D y/o Servicios: Síntesis de plataformas poliméricas basadas en hidrogeles y nanopartículas para captura de pesticidas, y liberación de drogas y medicamentos de forma controlada.
Investigador asociado del Centro de Nanomedicina, Diagnóstico y Desarrollo de Fármacos (ND3) de nuestra universidad.
Formación Profesional
- Licenciado en Química, Universidad de Chile, 2005.
- Químico, Universidad de Chile, 2006
- Dr. en Química, Universidad de Chile, 2011.
Líneas de Investigación
Proyectos Vigentes
Publicaciones
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Dr. Paula Alejandra Osorio
Perfil
Investigadora asociada al Laboratorio de Fisicoquímica
Mi trabajo de investigación está enfocado en el Diseño, Desarrollo y Caracterización de Catalizadores Heterogéneos para tres principales aplicaciones medioambientales:
Researchgate
linkedin
Scholar
Mi trabajo de investigación está enfocado en el Diseño, Desarrollo y Caracterización de Catalizadores Heterogéneos para tres principales aplicaciones medioambientales:
- Producción de Hidrógeno renovable mediante el Reformado Catalítico de compuestos provenientes de Biomasa.
- Valorización de Residuos principalmente neumáticos fuera de uso mediante Pirólisis Catalítica para la producción de Alquilbencenos en el contexto de una economía circular.
- Uso de Fotocatalizadores Heterogéneos para Reacciones de Oxidación o Reducción más amigables con el medio ambiente.
Researchgate
Scholar
Formación Profesional
- Licenciada en Química Industrial, Universidad Tecnológica de Pereira, 2005 (Colombia).
- Magister en Ciencias Químicas, Universidad del Valle, 2009 (Colombia).
- Doctora en Ciencias con Mención en Química, Universidad de Concepción, 2015 (Chile).
- Formación Postdoctoral, Laboratorio Procesos Térmicos y Catalíticos, Universidad del Bio Bio, 2019 (Chile).
- Formación Postdoctoral, Centro de Investigación y Desarrollo en Ciencias Aplicadas "Dr. Jorge J. Ronco" CINDECA, CONICET, 2021 (Argentina).
Líneas de Investigación
Proyectos Vigentes
Publicaciones